The Playground

New study out on the origin on the poly basic furin cleavage site on RBD of SarsCov2.

The base pair sequence of that site : CTCCTCGGCGGGCACGTAG has not been found in nature on any other virus, or eukaryotic cell for that matter.

But by a crazy coincidence it so happens that the sequence has appeared elsewhere : in a 2015 Moderna patent.

About five minutes of this video from the timestamp covers the basics, pun intended. (The bulk of the video however describes the NIH coverup of GoF research.)

No worries about the Nazis in 1938..

there is plenty of appeasement of BigPharma going on..

by the medical establishment

since well before 2021

mild myocarditis?????

Quote from Wyttenbach

Alert of German health care provider. At least 8x more confirmed adverse reactions than communicated.

The US source:: https://childrenshealthdefense…th-insurer/?itm_term=home

Quote from Mark U

But by a crazy coincidence it so happens that the sequence has appeared elsewhere : in a 2015 Moderna patent.

Not crazy at all: Moderna is a spin off of US state research. The play book started 2014 and as in all good Military Bio weapon research you want to have a new weapon that needs a new pre- battle counter agent for the protection of the own troupes and later fast vaccine like Omicron.

Omicron first has been spotted in North America and then later be placed in Africa by 4 Chinese diplomate. The path was always Construction in US lab - Final add-ons/test in Wuhan then distribution. In Canada it most likely was re-imported from Chinese folks in Vancouver.

Canadian Healthcare Professional Group Point to Concerns with the Pfizer COVID-19 Vaccines

Canadian Healthcare Professional Group Point to Concerns with the Pfizer COVID-19 Vaccines

The Canadian Covid Care Alliance (CCCA) critically analyzed the Pfizer COVID-19 vaccinations clinical trial reports in a new video report. They criticized

trialsitenews.com

The Canadian Covid Care Alliance (CCCA) critically analyzed the Pfizer COVID-19 vaccinations clinical trial reports in a new video report. They criticized the lack of a control group, calculations focused on relative risk instead of absolute risk, failure to check for early signs of adverse events, and the choice of endpoints for the study. TrialSite has previously reported on adverse events caused by the Pfizer vaccines as well as numerous positive looks—for example, numerous health systems report substantially lower COVID-19 death rates among vaccinated persons.

Undoubtedly not a feature in any mainstream news, The CCCA, a group of over 500 Canadian healthcare professionals, has released “The Pfizer Inoculations for COVID-19 – More Harm than Good” (PDF of the video available here). This video breaks down various reports released by Pfizer, investigates the data published, and concludes that the approved Pfizer vaccines cause harm to the public. What are the main concerns expressed by this Canadian group? Do they look at the problem objectively? While raising purported problems, do they showcase the benefits of the vaccine?

Control group cut after two months

A Dec. 2020 report summarized two months’ data from the Pfizer vaccine clinical trials. It states that in the 43,500 participants, divided into vaccine and placebo groups, the vaccine had 95% efficacy seven days after the second dose.

It should be noted that this 95% indicates relative risk reduction: 8 out of 18,200 vaccinated participants and 162 out of 18,300 placebo recipients contracted COVID-19. The risk of contracting COVID-19 in the placebo group was 0.88%, reduced to 0.04% in the vaccination group. Therefore, the absolute risk reduction of the vaccine came to 0.84%.

The trials were blinded, meaning that participants were not informed whether they were in the vaccine or placebo group. Phase 3 of the blinded trial was supposed to run until May 2023. However, after only two months of data collection in 2020, Pfizer un-blinded the study and offered the placebo group the opportunity to receive the vaccine and continue the trials in the vaccinated group. This meant that, as of early 2021, there was no longer a control group to measure the effectiveness or safety of the vaccines.

Participant deaths “not related” to vaccine

A Nov. 2021 report evaluated six months of clinical data from the Pfizer vaccine trials. This report showed 91.3% efficacy of the vaccines (relative risk reduction), but also revealed an increase in illness and death amongst the vaccinated group. A table of adverse events, included in the supplementary material of the report (Table S3), evidences an increase in adverse events in almost every category.

The CCCA also draws attention to the fact that the deaths in trial participants were inadequately addressed. According to the study, “During the blinded, placebo-controlled period, 15 participants in the BNT162b2 group and 14 in the placebo group died; during the open-label period, 3 participants in the BNT162b2 group and 2 in the original placebo group who received the BNT162b2 after unblinding died”. The study reported that none of these deaths were related to the BNT162b2 vaccine.

Biased from the start?

The Pfizer COVID-19 vaccines were developed, tested, and administered within one year, whereas vaccines are usually developed over five to ten years, according to CCCA. Phases II and III of the trials were combined, and the vaccine received Emergency Use Authorization (EUA) after 2 months of these trials. The trials were then un-blinded, but Phase III trials are still ongoing until 2023.

COVID-19 affects those over 75 years of age more severely, however, those over 75 years represented only 4.3% of trial subjects (refer to Section 11.4 Geriatric Use). Only 21% of participants had comorbidities, even though 95% of people who have died from COVID-19 had comorbidities.

The Pfizer trials also only focused on individuals who had never contracted COVID-19. The CCCA claims that to have data on natural and vaccine-induced immunity, Pfizer should have included those that have recovered from COVID-19 and received the vaccine, as well as those who have recovered from COVID-19 but remained unvaccinated. Pfizer only looked at symptomatic adverse events. Despite testing blood for antibodies after vaccination, they did not perform tests for biomarkers of pre-symptomatic disease, like inflammation, cardiac damage, hypoxia, or autoimmune disease.

Endpoints “Biggest Mistake” of the Pfizer Trials

According to the CCCA, the “biggest mistake” of the Pfizer trials included use of the wrong endpoints. The trials should have focused on mortality, illness, and spread, not hospitalizations.

Pfizer researchers tried to answer, declaring, “Do people who take the vaccines test positive for COVID-19 less often?” Their test answered “yes”, so the worldwide rollout of the vaccines commenced. Although the vaccines were not tested for reduction of transmission, COVID-19 vaccine passes are being used in many countries to reduce transmission

Testing Failures and Subjective Testing

According to the CCCA, the Pfizer trials only tested symptomatic participants for COVID-19, meaning that potential asymptomatic infections were missed. This failure to test everyone further biased the study while infusing subjectivity. There were also 166 participants (80 vaccinated, 86 placebo) ‘lost to follow-up’, meaning they could not be contacted (Table 3). The much-cited relative risk reduction figure of 95% may have fallen significantly if these participants were still included in the data.

The calculations also ignored “suspected, but unconfirmed cases,” where participants showed COVID-19 symptoms but were never tested: 1,596 in the vaccinated group, and 1,816 in the placebo group (page 42). If, for instance, all these individuals had COVID-19, then the relevant risk reduction would have been only 19%.

According to the CCCA, the FDA will not grant EUA to any vaccine with a risk reduction below 50%.

12–15-Year Old Adolescent Trial

Researchers published a report on the safety and efficacy of the Pfizer vaccine in children in May 2021. The study looked at 2260 participants aged 12 – 15, split into vaccinated and placebo groups. No participants in the vaccinated group contracted COVID-19, and 18 tested positive in the placebo group.

Among the vaccinated children, there was one serious adverse event reported: 12-year-old Maddie de Garay was hospitalized within 24 hours of receiving her second Pfizer dose. She experienced gastroparesis, nausea and vomiting, erratic blood pressure, memory loss, brain fog, headaches, dizziness, fainting, seizures, verbal and motor tics, lost feeling from the waist down, lost bowel and bladder control, and lost her ability to eat. Since then, she has been wheelchair-bound and fed via a tube. The FDA described Maddie’s injuries as “functional abdominal pain” (Page 30).

The CCCA believes that the FDA has abandoned the crucial health care principle “First, do no harm.” They claim that the FDA is aware that the vaccine may increase the risk of myocarditis in children but is still pushing for children to be vaccinated. They also state that those being vaccinated do not have appropriate informed consent based on their interpretation of the risk-benefit analysis. Parents are not aware of the limitation of a Pfizer study in kids aged 5 to 11. These limitations include “the lack of longer-term follow-up to assess the duration of immune responses, efficacy, and safety,” and “This study was also not powered to detect potential rare side effects of [the Pfizer vaccine} in 5-to-11-year-olds.” (See Discussion)

Rising incidence of heart issues and deaths in young people

In Canada, Ontario Public Health reported an increase of heart issues in young people between Dec. 2020 and Sept. 2021. There is also a rising awareness and increased reporting of professional athletes collapsing with health issues. Of course, this isn’t proof of any association let alone causation.

Israel’s Real Time News reported 21 FIFA players collapsing on the pitch in 2021 – five times the normal annual rate. Again, this news is used by vaccine critics, but no proof of association or causation is provided.

On Nov. 17, 2021, the FDA released documents ordered by a court to satisfy a Freedom of Information request by a group called the Public Health and Medical Professionals for Transparency. The group requested access to data used by the FDA to approve Pfizer’s COVID-19 vaccinations. The Post Marketing Pharmacovigilance Report submitted by Pfizer to the FDA showed over 1,200 deaths, and 25,000 nervous system adverse events.

Evidence of Conflict of Interest?

The authors of the Pfizer reports have a clear conflict of interest, with 84% of the authors either connected to Pfizer or BioNTech The founders of BioNTech, Ugur Sahin and Ozlem Tureci, were also the main authors of the six-month report. Since the rollout of the vaccines, the BioNTech stock value has increased by $9 billion.

Concerningly, since the rollout of the COVID-19 vaccines worldwide, the Centers for Disease Control and Prevention (CDC) changed the definition of “vaccine” on their website. It was “A product that stimulates a person’s immune system to produce immunity to a specific disease, protecting that person from that disease.” It was changed to “A preparation that is used to stimulate the body’s immune response against diseases.” There is no more mention of protection or immunity.

Ethical Considerations Regarding Unblinding

An opinion piece published in Frontiers in Public Health on Jun. 24, 2021 discussed the ethical considerations regarding unblinding participants. The authors offer an opposing view to the CCCA, as they argue that participants who received a placebo should be unblinded and offered the vaccine once the efficacy of the vaccine has been proven

Pfizer fudges...FDA obliges

Quote from Fm1

Concerns with the Pfizer COVID-19 Vaccines

The Pfizer Inoculations For COVID-19 – More Harm Than Good – VIDEO – Canadian Covid Care Alliance

Study Finds Vitamin D3 Important for Fighting Infections – Helps Strengthen Defenses Against COVID-19

Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome

Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome

Vitamin D is best known for its role in maintaining bone health and calcium homeostasis. However, it also exerts a broad range of extra-skeletal effects on…

www.frontiersin.org

Vitamin D is best known for its role in maintaining bone health and calcium homeostasis. However, it also exerts a broad range of extra-skeletal effects on cellular physiology and on the immune system. Vitamins D2 and D3 share a high degree of structural similarity. Functional equivalence in their vitamin D-dependent effects on human physiology is usually assumed but has in fact not been well defined experimentally. In this study we seek to redress the gap in knowledge by undertaking an in-depth examination of changes in the human blood transcriptome following supplementation with physiological doses of vitamin D2 and D3. Our work extends a previously published randomized placebo-controlled trial that recruited healthy white European and South Asian women who were given 15 µg of vitamin D2 or D3 daily over 12 weeks in wintertime in the UK (Nov-Mar) by additionally determining changes in the blood transcriptome over the intervention period using microarrays. An integrated comparison of the results defines both the effect of vitamin D3 or D2 on gene expression, and any influence of ethnic background. An important aspect of this analysis was the focus on the changes in expression from baseline to the 12-week endpoint of treatment within each individual, harnessing the longitudinal design of the study. Whilst overlap in the repertoire of differentially expressed genes was present in the D2 or D3-dependent effects identified, most changes were specific to either one vitamin or the other. The data also pointed to the possibility of ethnic differences in the responses. Notably, following vitamin D3 supplementation, the majority of changes in gene expression reflected a down-regulation in the activity of genes, many encoding pathways of the innate and adaptive immune systems, potentially shifting the immune system to a more tolerogenic status. Surprisingly, gene expression associated with type I and type II interferon activity, critical to the innate response to bacterial and viral infections, differed following supplementation with either vitamin D2 or vitamin D3, with only vitamin D3 having a stimulatory effect. This study suggests that further investigation of the respective physiological roles of vitamin D2 and vitamin D3 is warranted.

Concluding Remarks

Our ability to detect differences in the effects of vitamin D2 and vitamin D3 may have been negatively impacted by the relatively low statistical power and by the inclusion of two different ethnic groups among the 97 participants, since the transcriptome results from the two ethnic groups are clearly different; the number of participants represents a weakness of the present study. It will be important to replicate this study using a larger cohort in order to verify, or otherwise, the key findings from this study. From power calculations it is considered that for a whole human microarray-based gene expression study of this nature, and with gene expression changes of the magnitude we observe, at least 400 participants of each ethnic group should be recruited for each treatment, giving a total cohort size of 2,400. In this context, the biological interpretation of our findings should be considered as preliminary, requiring independent verification. A second limitation of this study was our failure to take account of the contribution of potential changes in blood cell composition across the seasons and across ethnicity; it is known that blood cell composition can vary significantly throughout the year (51, 71).

It is difficult to compare the findings of the present study with other reported in vivo studies because of the considerable differences in experimental design, including the use of supra-physiological vitamin D doses (up to 2,000 μg single bolus doses), different human population types and small sample sizes, which make statistical analysis not feasible [e.g. (33, 34)]. Furthermore, our study is unique in that it compared gene expression in participants given either of the two commonly used forms of vitamin D, vitamin D2 and vitamin D3. The present study evaluated overall expression changes in a complex blood cell population, which is also known to change in cellular composition across seasons (51). Furthermore, this study has focussed on identification of statistically significant pathway, or gene set, enrichment following sustained vitamin D supplementation, rather than a gene-focussed analysis; the latter approach is limited given the effect sizes and sample size of this study.

This study suggests that a more detailed consideration of the system-wide effects of these two forms vitamin D is warranted. This is perhaps of particular importance to at-risk ethnic groups, including black and South Asian populations who reside in northern latitudes. The studies would need to be time course-based (temporal) to track gene expression changes within individuals from baseline to defined sampling times and would need in-built control to account for seasonal gene expression changes. They would need to be designed specifically to answer whether different ethnicity or different vitamin D baseline concentrations give rise to different responses to vitamin D supplementation.

Since some pathways appear to be regulated specifically by vitamin D3, or in some cases, in opposing directions by vitamin D3 and D2, future studies should investigate whether vitamin D2 supplementation might counteract some of the benefits of vitamin D3 on human health. This possibility is prompted by the findings from this cohort that the circulating concentration of 25(OH)D3 within vitamin D2-treated participants was significantly lower after the 12-week intervention than in the placebo group, who received no vitamin D supplements – suggesting that the former might be depleted by the latter. The results from this study suggest that guidelines on food fortification and supplementation with specific forms of vitamin D may need revisiting.

Quote from RobertBryant

The Pfizer Inoculations For COVID-19 – More Harm Than Good – VIDEO – Canadian Covid Care Alliance

The paper:: https://www.canadiancovidcarea…-Good-REV-Dec-16-2021.pdf

6 months Pfizer phase III data clearly shows this vaccine is a criminal product causing more harm than benefit!

Just one table from the report. This is Pfizer data!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

Ultra-Vaccinated, Locked-Down New Zealand Sees Record Infection Rate

Ultra-Vaccinated, Locked-Down New Zealand Sees Record Infection Rate

New Zealand, one of the world’s most vaccinated nations, shattered its infection rate record today as citizens continued to protest the Commonwealth

trialsitenews.com

New Zealand, one of the world’s most vaccinated nations, shattered its infection rate record today as citizens continued to protest the Commonwealth nation’s draconian lockdowns and vaccine mandates.

A Record 6,137 New Cases

The government reported a record new 6,137 cases today smashing yesterday’s record total of 3,297 new cases.

As a result of voluntary vaccinations and a complex of lockdowns, penalties, and draconian mandates, nearly 4.5 million, or 88 percent, of New Zealand’s population had received at least one dose of a COVID-19 vaccine, and nearly 4 million, or 78 percent, had received two as of February 21. In addition, 2.2 million or 44 percent of New Zealand residents have taken boosters.

In the face of such world-class compliance, vaccines that were designed to target the Alpha variant appear to have little hope of reducing the transmissibility of the omicron variant.

New Zealand and Israel, High Vaccination and High Infection Rates

New Zealand’s situation has been mirrored in Israel and other highly vaccinated nations.

Hospitalizations and Deaths Manageable

While government officials expected cases to continue increasing until mid-March, they also expect hospitalizations – which stood at 250 today – and deaths (at a seven-day-average of zero today) to be manageable, and even reduce.

The contradiction of record-high cases and vaccinations, and increasing cases is forcing the government to rethink its pandemic rules. The government has announced that from Thursday onward it would only isolate people with confirmed COVID infections and their household contacts, rather than broad rules to isolate those who showed no symptoms but may have had exposure to the virus.

The government also pledged to make rapid antigen tests widely available.

Ardern Chased by Protesters

Meanwhile, New Zealanders, like other citizens around the world, have taken to the streets to protest ongoing mandates and other pandemic rules. Protesters were even seen chasing Prime Minister Jacinda Ardern away from a scheduled stop at a Christchurch primary school.

Protesters shouted, “shame on you” and “traitor” at the leader while others held signs threatening to put Ardern in prison or accusing her of being part of “The Great Reset” to increase global elite power

Covid-19 update: 6137 new community cases in NZ today, one further death

The daily number of community cases of Covid-19 in New Zealand has soared past the 6000 mark, with a record 6137 new cases today - almost double yesterday's…

www.rnz.co.nz

Quote from Wyttenbach

The Ukraine war will start within 2 days from now as politics just did end yesterday and Russia today misses the Munich meeting.

I didn't believe it, but now we see the brutal fact! Unfortunatley a very precise judgement of yours. Even the European politicians seem very "surprised" about the scale of this invasion.

And its always the normal people who have to pay the price!

For me this a further argument to support the LENR community to maybe one day get away with oil and gas dependency!

Is there anything what we can do as LF community to support the suffering people?

Quote from Wyttenbach

For Pfizer as of today for children::

Age: 12 .. < 17 :

Cardiac disorder: 2'742

Nervous system disorders : 7'983

Reproductive system disorders : 2'179

Blood disorder : 1'176

Now multiply this with 8 at least according to official health care data!

https://www.adrreports.eu/de/search_subst.html#

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If we look at both sides of the coin - is there a statistic that shows those deseaes in the group of unvaxxinated but infected and recovered children? Or is there no other side?

Quote from zorud

If we look at both sides of the coin

This is what the healthcare provider already did. 8x increase at least...

Quote from Fm1

As a result of voluntary vaccinations and a complex of lockdowns, penalties, and draconian mandates, nearly 4.5 million, or 88 percent, of New Zealand’s population had received at least one dose of a COVID-19 vaccine, and nearly 4 million, or 78 percent, had received two as of February 21.

How well vaccine kill you can see in India's sub state Kerala : https://www.mygov.in/covid-19

Today 2/3 of all India death from teh most vaccinated India state doing no treatment.

My mother in law (92 2x vaxx luckily no booster) got Omicron in daycare (Japan)...Then the doctor gave her the big gun from Merck. Two days some temperature already more than up again...

What about Omicron and treatment? Its just a quick soft flu.

Covid- Treatment for dummies:: https://worldcouncilforhealth.…t-Guide_01-Jan-2022-1.pdf

Quote from Wyttenbach

Covid- Treatment for dummies:: https://worldcouncilforhealth.…t-Guide_01-Jan-2022-1.pdf

I suggest adding a Vitamin B complex to the list as it looks like long COVID is caused by a thiamine deficiency

Research is finally catching up to the FLCCC, melatonin part of the IMask + Protocol

Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection

Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection - Cellular and Molecular Life Sciences

Numerous pharmaceutical drugs have been repurposed for use as treatments for COVID-19 disease. These drugs have not consistently demonstrated high efficacy in…

link.springer.com

Abstract

Numerous pharmaceutical drugs have been repurposed for use as treatments for COVID-19 disease. These drugs have not consistently demonstrated high efficacy in preventing or treating this serious condition and all have side effects to differing degrees. We encourage the continued consideration of the use of the antioxidant and anti-inflammatory agent, melatonin, as a countermeasure to a SARS-CoV-2 infection. More than 140 scientific publications have identified melatonin as a likely useful agent to treat this disease. Moreover, the publications cited provide the rationale for the use of melatonin as a prophylactic agent against this condition. Melatonin has pan-antiviral effects and it diminishes the severity of viral infections and reduces the death of animals infected with numerous different viruses, including three different coronaviruses. Network analyses, which compared drugs used to treat SARS-CoV-2 in humans, also predicted that melatonin would be the most effective agent for preventing/treating COVID-19. Finally, when seriously infected COVID-19 patients were treated with melatonin, either alone or in combination with other medications, these treatments reduced the severity of infection, lowered the death rate, and shortened the duration of hospitalization. Melatonin’s ability to arrest SARS-CoV-2 infections may reduce health care exhaustion by limiting the need for hospitalization. Importantly, melatonin has a high safety profile over a wide range of doses and lacks significant toxicity. Some molecular processes by which melatonin resists a SARS-CoV-2 infection are summarized. The authors believe that all available, potentially beneficial drugs, including melatonin, that lack toxicity should be used in pandemics such as that caused by SARS-CoV-2.

Concluding remarks

Beyond melatonin’s well-known antioxidant and anti-inflammatory actions which have proven the efficacy of this molecule in the treatment of diseases/ conditions where excessive free radical-mediated oxidative damage and hyperinflammation are causative factors [112,113,114,115,116], the studies summarized herein also support its use as a possible treatment for COVID-19 disease. Melatonin has been proposed as a potential effective inhibitor of the destructive inflammatory consequences of a SARS-CoV-2 infection [2, 4, 7, 11], an idea supported by observed and predicted improvements in the outcome of patients with this disease [95, 96] (Table 2). Numerous inter-related factors conspire to enhance the cytokine storm and multiple organ failure associated with COVID-19 disease severity and mortality, including elevated sPLA2-IIA, development of pro-inflammatory M1 macrophages, activation of HIF-1α, conversion to Warburg-type metabolism of immune cells, damage to mitochondria, massive release of cytokines, oxidative stress, etc. [117,118,119,120] (Fig. 1); each of these actions have been shown to be counteracted by melatonin. A center piece of this series of processes may be the alterations in mitochondrial physiology and the shift of glucose oxidation to the cytosol. This change in glucose handling markedly alters the metabolism of the mitochondria, which is critical to limiting cellular dysfunction, resisting disease, and preventing organismal death. Indeed, there are numerous maladies that are specifically classified as mitochondria-related diseases [121,122,123,124,125] with this category, including viral infections, such as SARS-CoV-2 [126,127,128,129].

If melatonin is in fact a significant antidote to SARS-CoV-2 infection, the development of a Warburg-type metabolism by hyperactive immune cells and other diseased cells [130], may be indirectly a major contributor to COVID-19 disease. This is because when intracellular glucose metabolism is reprogrammed from the mitochondria into the cytosol, the mitochondria can no longer synthesize acetyl coenzyme A (acetyl-CoA). This has high importance, since acetyl-CoA is a required co-substrate for intramitochondrial melatonin production [131], which normally occurs in these organelles of healthy cells but likely not in the mitochondria of highly inflamed cells [129]. Thus, in the absence of local melatonin synthesis in infected cells, the loss of this locally produced potent endogenously generated anti-inflammatory and antioxidant agent, the mitochondria lose a major portion of their protection against reactive oxygen species, inflammatory cytokines, etc., leading to their dysfunction; this contributes to a weakening of the cells with an increased susceptibility to cellular destruction by SARS-CoV-2. This would help explain the published data documenting the ability of melatonin to resist virus-related diseases, including that related to several different coronaviruses [102]. The ability of melatonin to reverse the Warburg effect in pathological cells in humans was recently documented, presumably allowing the mitochondria also to synthesize melatonin [129, 130].

The failure of melatonin to attract attention as a potential treatment for COVID-19 is somewhat disappointing considering a number of scientific/medical papers that have recommended its use. This may relate to a number of factors, including the lack of promotion of its therapeutic use for this disease by any influential group. Numerous already-available pharmaceutical drugs have been repurposed for the potential treatment of COVID-19. Yet, no organization/agency has proposed the use of melatonin even though it is much less expensive (sometimes a 100-fold less costly than the proposed prescription medications), and based on the outcomes of recent published trials [95, 96], it has efficacy in treating this condition. After an analysis of 27 publications related to the ability of drugs to successfully treat COVID-19, the authors concluded that melatonin is at least twice as effective as remdesivir or tocilizumab in reducing the inflammatory markers of a coronavirus 2019 infection [132]. Both remdesivir (Veklury) and tocilizumab (Actemra) are FDA authorized for use to treat select COVID patients suffering with a severe infection; both drugs have notable side effects and are given intravenously [133, 134]. In contrast, melatonin has a high safety profile and can be taken orally or administered by any other route [16]. Since melatonin is non-patentable and is inexpensive, the incentive of the pharmaceutical industry to support its use is lost. Finally, pharmaceutical drugs are sometimes enthusiastically advanced by individuals who stand to gain financially [135].

Better means of treatment for COVID-19 and other diseases, especially when a medication is less expensive and the toxicity of the suggested drug is minimal. All reasonable treatment options should equally be considered, not only those that have the backing of the most influential medical/pharmaceutical personnel [136]. Some in the profession have considered the COVID-19 pandemic an opportunity that should be exploited for personal gain. This is not permissible in medicine. There are examples of bias and/or conflicts of interest when treatment options for COVID-19 are considered [137].

A major purpose of the current report is to urge “leveling of the playing field” such that all potential reasonable options be considered to fight any serious, rapidly spreading disease, not only the COVID-19 pandemic [138]. The World Health Organization made a similar claim in 2014 during the Ebola outbreak in western Africa. In grave crises, such as during an Ebola epidemic or the COVID-19 pandemic, it is ethical to take advantage of all possible available and safe treatments even if their efficacy may not be definitively established especially when the drug has no serious side effects. Indeed, considering a large number of deaths that continue to occur worldwide due to SARS-CoV-2 infections, it may be unethical not to take advantage of any potentially safe treatments, especially if the vaccines become less effective due to continued mutations of the virus. People who are vulnerable and may be infected with such diseases should not have to wait for the development of a new vaccine which often requires months to years, an interval during which death of many patients may be the outcome. Additionally, the currently available mRNA COVID-19 vaccines are not safe for everyone, in particular for those who may have multiple allergies, and many individuals refuse to be vaccinated [139,140,141]. Moreover, the vaccines are not universally protective since vaccinated individuals still die of SARS-CoV-2 infections. The use of melatonin would be especially advantageous because it can be orally self-administered, it is low in cost, and it lacks significant toxicity. This applies especially to impoverished regions of the world where the populace has fewer financial resources to devote to the treatment of this disease and where health care is not readily available. Additionally, although this paper considers melatonin as a sole treatment for SARS-CoV-2 infections, it has also been suggested as a co-treatment with vaccines to improve their efficacy [15, 142,143,144] and in combination with other drugs [132]; this latter suggestion would be especially applicable when the medications have different but complimentary mechanisms of action to those of melatonin. Finally, to avoid or to reduce the likelihood of pervasive viral infections (e.g., by the highly deadly zoonotic Nipah virus currently invading India or the Omicron variation of SARS-CoV-2)) in the future, the profession should be more proactive as opposed to being reactive.

Quote from Fm1

In grave crises, such as during an Ebola epidemic or the COVID-19 pandemic, it is ethical to take advantage of all possible available and safe treatments even if their efficacy may not be definitively established especially when the drug has no serious side effects. Indeed, considering a large number of deaths that continue to occur worldwide due to SARS-CoV-2 infections, it may be unethical not to take advantage of any potentially safe treatments, especially if the vaccines become less effective due to continued mutations of the virus.

Something most of us have been advocating for here since the beginning. Unfortunately, most medical professionals, health care agencies and organizations, whose sole stated purpose was to safeguard our health, decided instead to pursue power, political agendas, and money. Our best interests came last.

Quote from Shane D.

Unfortunately, most medical professionals, health care agencies and organizations, whose sole stated purpose was to safeguard our health, decided instead to pursue power, political agendas, and money.

I predicted this war more than 3 months ago as it was clear that all the money the criminals collected during the world wide CoV-19 terror regimes can only be secured if the is more suppression. The mafia is waiting for the second big Pfizer payout as they exactly know the lawyers will shredder this criminal company within a few years - once somebody found a way to make profit even with this....

Quote from Shane D.

Unfortunately, most medical professionals, health care agencies and organizations, whose sole stated purpose was to safeguard our health, decided instead to pursue power, political agendas, and money. Our best interests came last.

Well, they saved millions of lives and gave us a vaccine that virtually eliminates the risk of severe illness or death. So who cares what their motivation is? If you are saying that capitalism is somehow unethical because drug companies save your life to make a profit, I don't get that. Who cares why they do it, as long as they do a good job. They deserve a fat profit.

Also, I have never heard a medical professional say his or her sole purpose is to safeguard health, and he is not in it for the money. Most doctors make a very good living, and they do not deny it. People want to go to medical school and become doctors to get rich. Do you have a problem with that?

Frankly, I think you are wrong about medical researchers. The people I know at the CDC are dedicated, and they work for peanuts considering how much good they do.