Cleveland Clinic Retrospective Study Indicates Obese Patients Face Higher Probability of Long COVID
Cleveland Clinic researchers recently completed a study indicating long-term COVID-19 complications may be more pronounced in individuals struggling with obesity. Led by Dr. Ali Aminian with Cleveland Clinic’s Bariatric and Metabolic Institute in the Department of General Surgery, the published study indicates that those diagnosed with moderate to severe obesity face a 30% higher risk associated with long-COVID.
The Study
The Cleveland Clinic team performed a retrospective analysis of a prospective, observational, IRB-approved clinical registry of all patients tested positive by RT-PCR for SARS-CoV-2 infection within the Cleveland Clinic Health System (CCHS) from March 11, 2020, to July 30, 2020, with a follow-up review by January 27, 2021.
Several patient categories were excluded, from those with no Body Mass Index (BMI) data to individuals with a history of organ transplant, those currently pregnant, and more.
The Findings
The risk of hospitalization was 28% and 30% higher in patients with moderate and severe obesity, respectively, as compared to those patients with what is considered a normal BMI. Patients that were classified as moderate and severe required a 25% and 39% greater need for diagnostic tests.
Moreover, the investigators identified comparable patterns when ordering diagnostic tests evaluating cardiac, pulmonary, vascular, renal, and gastrointestinal systems, and mental health.
Among other things, a key indirect effect is associated with the study: that risk signs and symptoms associated with select body organs increase in patients with moderate and severe obesity compared to those with a normal measurement.
The study team argues that these findings indicate patients with obesity face higher risks for post-acute sequelae of COVID-19 (PASC) or “Long Covid.”
Study Limitations
Of course, this study has some limitations. TrialSite provides a list below:
Observational study with retrospective design from one single healthcare system
Use of electronic records and inherent limitations associated with data capture
Reason or hospitalization or other interaction with the hospital not known
True prevalence of PAS remains unknown
Other comorbidities could impact results
The study team found that the data suggests that moderate and severe obesity, a measurement of BMI ≥ 35 kg/m2, is associated with a greater risk of long-COVID. The authors declare that if further studies substantiate these results, a more proactive care plan for patients with obesity following COVID-19 infection is needed.
Lead Research/Investigator
Ali Aminian, MD
James Bena, MS
Kevin M. Pantalone, DO
Bartolome Burguera, MD