Why vaccination makes things worse.

https://science.sciencemag.org/content/sci/373/6555/648.full.pdf

See Kerala/Israel/USA California

A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally detected in
California, carries spike glycoprotein mutations S13I in the signal peptide, W152C in the N-terminal
domain (NTD), and L452R in the receptor-binding domain (RBD). Plasma from individuals vaccinated
with a Wuhan-1 isolate–based messenger RNA vaccine or from convalescent individuals exhibited
neutralizing titers that were reduced 2- to 3.5-fold against the B.1.427/B.1.429 variant relative to
wild-type pseudoviruses. The L452R mutation reduced neutralizing activity in 14 of 34 RBD-specific
monoclonal antibodies (mAbs). The S13I and W152C mutations resulted in total loss of neutralization
for 10 of 10 NTD-specific mAbs because the NTD antigenic supersite was remodeled by a shift of the
signal peptide cleavage site and the formation of a new disulfide bond, as revealed by mass
spectrometry and structural studies.

For gamma the reduction was just 70% in average here we talk of factors 3 after an already vanning protection for Pfizer. Only 1.3.5.1 was worst so far. But now we have W152C that clears all vaccines...

It is common medicine knowledge since 100 years. Never vaccinate into a pandemic. This may be works for circuit boards...

Some differences among the mutations:

https://www.medrxiv.org/content/10.1101/2021.08.19.21262139v1.full.pdf

In general infection protects much better than vaccination. Some rare mutations are slightly worse for some combination of infected e.g. by alpha then epsilon.xyz

Alpha was the only non-resistant variant

associated with breakthrough infection in vaccinated cases. Overall, fully vaccinated cases were significantly

more likely than unvaccinated cases to be infected by resistant variants (77.6% versus 47.7%, p=1.96e-08)

(Figure 2B, top and Table 1), but not by variants associated with increased infectivity (84.7% versus 76.8%, p

0.092) (Figure 2B, bottom and Table 1). The distribution of variants in immunocompetent and

immunocompromised patients was similar (Figure 2A). Infections by the gamma and delta variants, which

cause more pronounced decreases in Ab neutralization relative to most of the other resistant VOCs12,21 (Figure

2A, left) were increased in fully vaccinated breakthrough infections as compared to unvaccinated infections. In

contrast, variant distribution in unvaccinated cases, with alpha and epsilon predominant (Figure 2B, right), was

similar to estimates of prevalence locally in the community and in the state of California during the study

period1

Prominent Indian Physician Verifies Huge Impact of Ivermectin in Curbing Second Delta-Variant Wave in India

Prominent Indian Physician Verifies Huge Impact of Ivermectin in Curbing Second Delta-Variant Wave in India

TrialSite chronicled closely the use of ivermectin-based home medicine kits in India’s largest state, Uttar Pradesh, and other states during the second

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TrialSite chronicled closely the use of ivermectin-based home medicine kits in India’s largest state, Uttar Pradesh, and other states during the second wave of the pandemic starting in March and running through April. TrialSite shared that by June cases plummeted to what is today’s far more contained situation. TrialSite had accumulated evidence that the World Health Organization (WHO) wanted this covered up. So impressive was the Indian effort in Uttar Pradesh that WHO had to report on the success, less the material information that state and local health authorities use of ivermectin in their aggressive home-based test and treatment regimen. This effort is either omitted in Western mainstream media or discounted as not proven by what are often disqualified fact checkers. Recently a prominent Indian physician, Dr. Lenny Da Costa, went on the record to discuss “The True Story of India” involving ivermectin treatments there. While propaganda and misinformation in the West rages, the top Geriatrician, Preventive Cardiologist, and anti-aging specialist from the coastal Indian state of Goa gave a breakdown of exactly how ivermectin was used and what in fact were the results. He notes that the drug is still pervasively used despite media accounts to the contrary.

Uttar Pradesh’s Amazing Turnaround Against Delta Wave

As TrialSite shared with much of the world by May 12, Uttar Pradesh’s Director General of Medical and Health Services, Dr. Anshul Pareek led that state’s Health Department through the COVID-19 crises, establishing India’s most populated state with over 220 million people to become the first in the world’s second most populous nation to establish ivermectin as part of a large-scale prophylactic program with a focus on 1) close contacts of COVID-19 patients; 2) health workers and 3) general care of COVID-19 patients and eventually an aggressive home care program. WHO celebrated the Uttar Pradesh effort but censored material information–that ivermectin was an key part of the strategy to overcome the COVID-19 surge.

On May 28th TrialSite chronicled growing media suppression of the facts on the ground in India.

By May 30, 2021 TrialSite shared in “Unprecedented Pandemic Turnaround in Uttar Pradesh with Dramatic Decline in Cases: Time to Smell the Coffee” the incredible turnaround public health officials in Uttar Pradesh, a state with over 220 million people, accomplished using an ivermectin-based home treatment protocol. Days later on June 6 the rapid turnaround continued as reported in “Uttar Pradesh COVID-19 Case Decline Continues as Authorities Lift Restrictions in 72 of 75 State Districts: What was in those Medicine Kits?” While the WHO recognized the incredible work ongoing in India they omitted the use of ivermectin in what TrialSite considers some form of a coverup. Why would such material information be suppressed?

The Interview

Recently Dr. Lenny Da Costa verified all of the accounts TrialSite reported on this Spring. Dr. Da Costa shared that the home medicine kit included ivermectin, Doxycycline, Zinc, and Vitamin CI and in fact reports a new kit is now offered to kids there given the higher infection rates among that cohort.

Touting the incredible turnaround thanks to the aforementioned move by public health authorities in Uttar Pradesh, Da Costa shared with the interviewer verified the skyrocketing cases and the rapid decline, based on the massive public health program involving the free home medicine kits. Dr. La Costa declared that key to the success was the ability of ivermectin to inhibit transmission of the virus, especially among household contacts, which seemed to work incredibly well.

As Da Costa is from Goa, she shared on the account TrialSite reported on, that Goa backed off from the protocol due to reasons “other than healthcare” by June 20.

Media Propaganda and Misinformation

As TrialSite monitors clinical research and innovative care programs around the world during the pandemic Dr. La Costa verified what this media reported on—Western media censorship and material omission as to what was in fact working in India during the second Delta-triggered crisis.

La Costs reported that WHO’s Dr. Soumya Swaminathan issued warnings about the use of ivermectin that triggered a series of actions and reactions in India. For example a group of physicians and then lawyers filed lawsuits against the WHO director and WHO for criminal negligence, among other things. This created significant pressure within government as the WHO wields considerable clout not to mention a budget used for low-and-middle income countries.

Thus India’s apex research institute the India Council of Medical Research (ICMR) took down a recommendation for ivermectin. But that didn’t stop some states, including Uttar Pradesh from continuing to include the generic antiparasitic drug in its public health protocol targeting SARS-CoV-2. That’s because while the central government in India wields power it does not run medical care at the state level. Thus by June 29 with central authorities under pressure from the WHO to take down the ivermectin recommendation, states such as Uttar Pradesh doubled-down, even introducing a pediatric protocol, given the increased number of younger infections.

Da Costa reports also that a majority of physician practices use ivermectin at the local level, including himself, across the states in this vast country. He shared that “the successful containment in the second wave was primarily due to ivermectin, Doxycycline, Zinc and Vitamin C” treated early on, that is right when the first symptoms appear. Early care was the key to success in India turning around the deadly second, Delta variant-triggered surge.

The Profile: Dr. Lenny Da Costa

Dr. Lenny Da Costa is a Consultant Geriatrician, Preventive Cardiologist and anti-aging specialist. On qualifying from The Goa Medical College, he started his basic practice in Goa. It was during this period, he realized, that one of the biggest problems ailing the community was morbidity and mortality due to ageing.

This led him to do his specialty in Geriatric Medicine form M S Ramaiha Medical College Bangalore. On completion he pursued his training in the practice of Anti-aging and Preventive Cardiology.

He is amongst the few in the country certified by the International Board of Clinical Metal Toxicology USA as a FCMT, and the only one from Goa and Western Maharashtra (outside Mumbai) trained to administer chelation therapy.

He has also been certified by the Academy of Anti-Aging Medicine of India and Affiliate of the American Academy of Anti-Aging Medicine in the field Anti-Aging Medicine and in the use of Bio-identical Hormone Replacement Therapy. He has further trained in the use of Ozone Therapy under the auspices of Indian Ozone Society.

Dr. Da Costa is a member of a number of Medical Organizations including the IMA, IMA CGP, Research Society for the Study of Diabetes in India, GPA Greater Mumbai, Geriatric Society of India, to name a few. He is currently the Gen Secretary of the Indian Society for the Study of Metal Toxicology and Chelation Therapy (a nationwide organization that conducts workshops, training sessions, conferences for Chelation Therapy practitioners).

Dr. Da Costa has over the last 5 years treated more than 12000 patients suffering from IHD, CAD and other chronic degenerative disorders, all over Maharashtra and Goa. Dr Da Costa currently visits affiliate clinics in Ratnagiri, Chiplun, Mahad, Mangaon, Panvel, Mumbai, Thana, Nasik, Satana, Ahmednagar, Kholapur, Sangli while having his own clinic at Pune also.

Call to Action: Listen to the interview, read the numerous TrialSite accounts as well as hundreds of articles and interviews in India about the ivermectin-based home medicine kit that supported an amazing turnaround and is still in use today in Uttar Pradesh and some other states. Ask yourself why the media in the West censored this information? Why would the WHO commend the Uttar Pradesh effort publicly while omitting the involvement of ivermectin? Could it be that a confluence of governments, industry and NGOs already established a vaccine-centric pathway that couldn’t afford to have non-pharma competition, even with numerous real world data points that lives were being saved?

Want to See your 11-year Old Again?’ Judge Abuses of Judicial Power in Move to Essentially Force COVID-19 Vaccination

‘Want to See your 11-year Old Again?’ Judge Abuses of Judicial Power in Move to Essentially Force COVID-19 Vaccination

It would appear that a Cook County, Illinois brought the COVID-19 vaccination mandate movement directly into a standard child custody case, sua sponte,

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It would appear that a Cook County, Illinois brought the COVID-19 vaccination mandate movement directly into a standard child custody case, sua sponte, that is using his authority without the formal prompting of the other party. Judge James Shapiro stripped an Arizona mother of her parental rights because she hasn’t yet been vaccinated for COVID-19. Apparently Rebecca Firlit, the mother now divorced for seven years, shares custody of her son with her ex-husband and appeared in court via a Zoom meeting to discuss general child custody matters. In an unusual move to say the least, Judge Shapiro impulsively exploited his powers to provoke Ms. Firlit to get a vaccine by ruling that she cannot see her son. The strongest of human bonds–a mom and her child–inhibiting such a vital connection shouldn’t be done arbitrarily or capriciously. But seemingly that’s exactly what Judge Shapiro did here.

In an interview with FOX 32 News in Chicago, Ms. Firlit, now residing in Arizona shared that the court hearing, attended via web meeting service Zoom, was about other child custody matters when Judge Shapiro, in a spontaneous and unrelated interrogatory demand to know if she had been vaccinated.

Firlit responded to the judge that she hadn’t as she was concerned that she has experienced adverse reactions to other vaccines in the past. Then without asking any other questions about her health background, conditions, or experiences with other vaccines impulsively employed his power to essentially force a vaccination, that is if she wants to see her children she must get the COVID-19 vaccine. Until then he forbade her from seeing her 11-year old son.

In the FOX 32 News interview Firlit shared “It had nothing to do with what we were talking about. He was placing his views on me and taking my son away from me.” Annette Fernholz, Firlit’s attorney argues to FOX 32 News that the judge crossed a legal line declaring: “The trial court clearly exceeded its authority in sua sponte suspending the mother’s parenting time when the issue before the court was child support,” Fernholz told Fox News in a statement. “The father did not bring this issue before the court. The mother did not know her parenting time was being discussed when she went to zoom court on August [10]. The judge deprived her of notice and a full hearing on the issue. The issue is now before the Illinois appellate court.”

First TrialSite acknowledges there could be more to the story. The judge did not respond to media requests and we haven’t directly interviewed the parties. TrialSite verified this story from several sources. Few mainstream media are covering the shocking incident.

In the meantime mounting vaccine mandates at places of employment create ever more pressure on those that have opted to not be vaccinated for whatever reason. TrialSite suggests that the U.S. Food and Drug Administration (FDA) rushed the approval of the Pfizer-Biotech vaccine more than likely in, in part, to persuade vaccine hesitant candidates to change their minds. Of course we argued the authorization, which was by no means standard or normal, also serves to back employer mandates.

Legislatively the precedent does exist for vaccine mandates according to a Johns Hopkins University, Bloomberg School of Public Health professor Joanne Rosen, JD. According to Rosen the authority is present in a state to mandate vaccines. Moreover the academic referred to a 1905 court cases “Jacobson vs. Massachusetts” where the town of Cambridge introduced an ordinance three years earlier in 1902, mandating all adults to get vaccinated or re-vaccinated against smallpox. For those that didn’t comply with the rule back then needed to pay a $5 fine, undoubtedly worth a lot more in 1902.

Call to Action: TrialSite Community—this shocking and egregious action indicates a pattern. Remember there are now many lawsuits involving patients and their families suing hospitals just so they can get treated with ivermectin. So on the one hand increasingly institutions, some private sector and some public increasingly inhibit access to material healthcare information and actual treatment while on the other hand growing mandates and actions such as this one indicate a potential threat to individual liberties. From one point of view those liberties cannot be enjoyed if the commons are materially enough under threat. On the other hand many argue basic individual liberties, such as not having to be subject to mandates, lies at the core of Constitutional freedoms. Now in this latest case where a judge seemingly in sua sponte suspends the ultimate bond—a mother and child over his opinion that she needs to get a vaccine. This reeks of an abuse of judicial power and crosses the line of acceptability. He isn’t a doctor first and foremost and the topic wasn’t even relevant to the particular court hearing. What are your thoughts?

Can COVID-19 Vaccines Be Mandatory in the U.S. and Who Decides? | Johns Hopkins Bloomberg School of Public Health

Once COVID-19 vaccines are widely available, could they be made mandatory and, if so, what entities could enforce this?

publichealth.jhu.edu

Mutation rate of Covid19 virus at least 50 % higher than thought.

The virus that causes COVID-19 mutates almost once a week—significantly higher than the rate estimated previously—according to a new study by scientists from the Universities of Bath and Edinburgh. Their findings indicate that new variants could emerge more quickly than thought previously.

wow! the human body already doing gene warfare..."

"APOBEC3 proteins have clear roles in conferring intrinsic host resistance to infection to different viruses due to their ability to directly act on viral genomes, thereby generating mutations or blocking viral nucleic acid synthesis.

https://www.ncbi.nlm.nih.gov/p…ucleic%20acid%20synthesis.

Article from BBC.

New Zealand woman dies after receiving Pfizer vaccine.

"New Zealand has reported what it believes to be its first death linked to the Pfizer Covid-19 vaccine.

An independent vaccine safety monitoring board said the woman's death was "probably" due to myocarditis or inflammation of the heart muscle.

It also noted there were other medical issues which could have "influenced the outcome following vaccination".

European regulators say myocarditis is a "very rare" side effect and that the vaccine's benefits outweigh the risks.

The official cause of death has not yet been determined.

However, the Covid-19 Vaccine Independent Safety Monitoring Board said the myocarditis was "probably due to vaccination".

"This is the first case in New Zealand where a death in the days following vaccination has been linked to the Pfizer COVID-19 vaccine. While the Centre for Adverse Reactions Monitoring has received other reports of deaths in someone recently vaccinated, none are considered related to vaccination," it said in a statement.

The woman's death is being investigated further and a coroner is due to rule on the case. Officials have not released any further details, including the woman's age.

The European Medicines Agency has highlighted myocarditis as a "very rare" side effect of the Covid vaccines made by Pfizer and Moderna, adding that the side-effects were more common in younger men."

Quote from ZenoOfElea

The European Medicines Agency has highlighted myocarditis as a "very rare" side effect

In fact +5 cases/mio with death or 50/mio in total. Not so rare but occurs earliest 2 week after vaccination.

Just to remind you 2 weeks is also the average duration of the high immune suppressive phase after the Pfizer gen therapy.

Swiss company had great success (97% protection for severe disease) with a classic SARS-COV-1 antibody found in people that have been infected 2004 and did resist to SARS-COV-2

HUMABS BioMed

Company already sold to https://www.vir.bio/

This antibody definitely will have no immune suppressive effect!

Chinese Study Adds to Evidence for Substantial Long-COVID Problem

Chinese Study Adds to Evidence for Substantial Long-COVID Problem

A prominent team of researchers in China including Prof. Bin Cao, with the National Clinical Research Centre for Respiratory Diseases, China-Japan

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A prominent team of researchers in China including Prof. Bin Cao, with the National Clinical Research Centre for Respiratory Diseases, China-Japan Friendship Hospital compared 1,276 patients discharged from Wuhan-based Jin-Yin-Tan Hospital during the first phase of the pandemic last year with residents from that city not infected. The pandemic started in Wuhan, yet the origins of the virus haven’t been discovered as of yet. Monitoring the patients twice in the year after the first reports of symptoms, the research team discovered a number of similar long term effects due to COVID-19 from muscle weakness and sleeping problems to fatigue, dizziness, headaches and shortness of breath. Considered a Real World Evidence-based study, by month six 68% of subjects complained of a minimum of one COVID-19 symptom, declining to 49% after the annual check in. Breathing problems actually increased with time for many of these patients apparent in 26% to 30% of the patients. While mental health issues at half year surfaced in 23% of the patients and by year one up to 30%. The Chinese investigators associated worse long-COVID with more severe bouts of SARS-CoV-2 infections. Generally a substantial portion of COVID-19 patients experience some form of “LONG-COVID” leading to a number of complaints most commonly shared were muscle weakness and fatigue. It’s as if the human body expends great energy and effort to rid the virus and those symptoms persist.

Funded by a number of public and private donors, from the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences to the National Natural Science Foundation of China to many others such as the Jack Ma Foundation, the Chinese research adds to mounting evidence for serious trouble for at least some COVID-19 patients

No one knows the precise incidence of long-COVID but rates appear to wane over time. Some earlier studies indicated that between 20% and 33% of people with COVID-19 experienced long-COVID symptoms as reported by the UK government

A more recent study led by an investigator group called the IVY Network Investigators and the CDC COVID-19 Response Team reported in a study that among 292 respondents, 94% (274) reported experiencing one more symptoms at the time of testing and that about 35% of those who tested positive for COVID-19 experienced a range of symptoms that lasted longer than three weeks. Even some studies indicate children can experience a form of long-COVI

Those whose disease progressed to something more severe seem to link to longer cases, indicating a higher potential for long-COVID. For example, according to one study 80% of those who were admitted to the hospital with severe COVID-19 experienced long-term problems, such as muscle weakness, fatigue and other condition

TrialSite has covered some long-COVID studies and will continue to track this important topics

The prevalence of long COVID symptoms and COVID-19 complications - Office for National Statistics

Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network — United States, March–June 2020

www.ncbi.nlm.nih.gov

Will the ‘AY3’ Variant Spell More Trouble in Israel?

Will the ‘AY3’ Variant Spell More Trouble in Israel?

A new and possibly more transmissible and deadly SARS-CoV-2 Delta associated variant of concern surfaced in Israel, raising concerns for the vaccination

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A new and possibly more transmissible and deadly SARS-CoV-2 Delta associated variant of concern surfaced in Israel, raising concerns for the vaccination program among other issues. Based on the Delta variant, the AY3 strain results from ongoing mutations in this Eastern Mediterranean nation. As it turns out a number of mutations are surfacing including some that are considered more “virulent.” Now ten people were identified as infected with AY3, eight recently returned from international trips while two were infected locally. Could AY3 represent the final trigger for more onerous lockdowns to come?

Last week Dr. Asher Shalman, Health Ministry Department of International Relations Director informed the Knesset Law and Constitution Committee about the risks from AY3 which he believes originated in South America. Days later the ministry shared that 10 cases were associated with AY3.

The Delta Surge

Israel now faces its worst surge yet during the pandemic despite high vaccination rates. As of August 28 the health authorities there reported 11,177 news cases representing a new record high. Daily deaths based on a 7-day average hover at 25. TrialSite has reported large numbers of breakthrough cases meaning the vaccinated are not only transmitting the virus but also getting infected and landing in the hospital.

Consequently Israel commenced its third booster program despite the fact that calls for vaccine equity from the World Health Organization (WHO) pointed to requests for a temporary hold on any booster programs.

AY3

The Jerusalem Post reported Prof. Cyrille Cohen, head of immunotherapy laboratory at Bar-Ilan University declared “AY3 is a subtype of the Delta variant, which falls under the category of what we have called the Delta -Plus variants.” Dr. Cohen continued that all of these variants associated with Delta “…present a mutation called 417, which is suspected to help the variant to escape antibodies.”

The AY3, again a subtype of Delta, actually makes up a number of new variants known as Delta-Plus variants.

Is Thailand’s PM Advancing Beyond the Chinese (Zero-Tolerance) & American (Vaccine-Centric Eradication) Paradigm Acknowledging the Need to Coexist with COVID-19?

Is Thailand's PM Advancing Beyond the Chinese (Zero-Tolerance) & American (Vaccine-Centric Eradication) Paradigm Acknowledging the Need to Coexist with COVID-19?

Perhaps they make politicians more honest in Thailand?  Recently Prayut Chan-o-cha, the nation’s Prime Minister established expectations that COVID-19

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Is Thailand’s PM Advancing Beyond the Chinese (Zero-Tolerance) & American (Vaccine-Centric Eradication) Paradigm Acknowledging the Need to Coexist with COVID-19?

TrialSite Staff

August 29, 2021

1 Comment

Perhaps they make politicians more honest in Thailand? Recently Prayut Chan-o-cha, the nation’s Prime Minister established expectations that COVID-19 will be around for a long time. Put another way, according to local media sources there is a growing recognition that at least among the heads of this Southeast Asian nation that the people will have to learn to live with the virus. This is of course a very different message resonating out of politicians in America that in similar fashion to Chinese Communist Party (CP) politicians, seek to eradicate the pathogen, completely and totally from existence. In China the CP employs the “Zero-Tolerance” policy using a combination of invasive technology, continuous testing and data-driven lockdowns and quarantines, not to mention strict border controls leading to what has been thus far a good track record of keeping infections out of the country. But with a recent outbreak due to Delta, a number of prominent economists noted that the burden of the heavy costs of this 24X7 zero-tolerance operation are placed on the shoulders of the local municipalities—many of them of which ascended financially into the red. While America employs the use of pharma and government industry complex—that is a vaccine-centric approach to completely and thoroughly eradicate the virus. In both cases the state begins to uncomfortably trump individual liberties to enforce the particular version of the eradication model. Of course Americans’ taste for civil liberties and democracy oppose those expectations of a CP-dominated China. Trialsite raises the specter that in both cases the sustainability of both versions of total COVID-19 eradication are in question, and that the Thai Prime Minister doesn’t have the same sense of hubris and omnipotence perhaps as do his Chinese and American counterparts along with governing bureaucrats.

Raised during a meeting of the Centre for COVID-19 Situation Administration (CCSA) last Friday, Gen Prayut suggested the country adjust its COVID-19 management strategy declaring that the people need to “Learn to live safely with COVID-19” given the dynamic, evolving nature of the pathogen points to the fact that attempts at total and complete eradication may be futile according to sources reports the Bangkok Post.

Brief Update Delta Surge in Thailand

Thailand’s experience with the pandemic was minimal up and until the Delta variant materialized in the country by the Spring of this year. From minimal cases for much of the year by August 13 the country reported 23,418 new cases in a day. By August 18 a record 312 lives were lost due to the Delta variant of SARS-CoV-2. By August 22 the cases now appear to be headed downward according to data from COVID-19 Data Repository by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University.

Not Vaccine Nation Yet

According to data from Our World in Data only about 9.2% of the Thai public have been vaccinated by August 24. Those with at least one jab represent about 31.1% of the population in this nation with nearly 70 million inhabitants.

TrialSite has discussed vaccine challenges in Thailand starting with the piece “Royal Crony Capitalism or a Regal Choice for Vaccine Production.” Originally also dependent on Chinese vaccines, TrialSite reported that by July “Thailand Moving off of Sinovac in Favor of AstraZeneca: Are more Nations to Follow?”

Living with COVID-19—what does this look like?

Generally the Thai Prime Minister according to the Bangkok Post sources suggests the Thai CCS established “a balance between COVID-19 control measures and allowing people to go about their normal lives and economic activities.”

The Bangkok Post—the Phuket Sandbox scheme which commenced on July 1 as well as the Samui Plus model on July 15. As the nation depends heavily on tourism for its livelihood, these initiatives are associated with the travel and tourism sector.

The Thai PM’s vision for moving forward includes vaccines, therapies and balanced public health measures but the key difference e.g. the various public health measures such as “social distancing, mask-wearing, hand-washing, temperature-checking and using the Thai Chana app” reported the Bangkok Post.

The Bangkok Post reminded readers of intensive research and development along with the development of domestically developed and produced vaccines. In fact Thailand’s Chulalongkorn University’s Faculty of Medicine now works on an indigenous mRNA vaccine called ChulaCOVD-1 recognizing the need for public health self-sufficiency. Marketplace dynamics can leave low-and-middle income countries (LMICs) on the wrong side of the transaction too often.

Medical Practice or Medical Experimentation? Arkansas Doctor Dares to Use Ivermectin

Medical Practice or Medical Experimentation? Arkansas Doctor Dares to Use Ivermectin

On August 26, CNN interviewed Surgeon General Vivek Murthy, who went on the record about the exploding use of Ivermectin to target COVID-19. He asserted

trialsitenews.com

On August 26, CNN interviewed Surgeon General Vivek Murthy, who went on the record about the exploding use of Ivermectin to target COVID-19. He asserted that the drug is not recommended to treat COVID-19. Murthy declared the, “best way to protect against COVID-19 is the vaccine.” He followed by declaring that if one gets infected with SARS-Cov-2, the virus behind COVID-19, there are treatments such as steroids or monoclonal antibodies. Murthy declared that misinformation is the culprit behind rising Ivermectin use. This interview went alongside a CNN piece reporting that the Arkansas Medical Board is now investigating a doctor for prescribing the anti-parasitic drug “thousands” of times for the treatment of the novel coronavirus, including for inmates in an Arkansas jail. As TrialSite has shared in its Ivermectin fact check, there is much evidence for its efficacy, and it is legal for physicians to prescribe ivermectin off label for COVID-19. But this must be done in the standard way, that is with both full disclosure of any risks and consent of the patient.

FDA Warnings

The US FDA in its messaging has somewhat conflated the use of ivermectin for animals, as opposed to the version developed for humans, and the recent CNN article reinforced this confusion. However, a careful reading of the latest message indicates acceptance for use for indicated use. The FDA declares they have, “not reviewed data to support use of ivermectin in COVID-19 patients to treat or to prevent COVID-19; however, some initial research is underway.” They go on to instill fear by declaring, “Taking a drug for an unapproved use can be very dangerous. That is true of ivermectin, too.” FDA in some way provides misinformation, declaring that “initial research is underway.” In fact, there are many Phase 3 trials underway, including at least a couple in the United States. Phase 3 studies aren’t “initial research,” but rather the last step along the way toward acceptance or not. The reality is that many drugs, and even alcohol, can be dangerous if misused. In fact alcohol is responsible for 261 deaths per day. FDA fails to inform that a physician can, based on their judgment, prescribe Ivermectin off-label for COVID-19, at least until the law changes. While it is not uncommon that Ivermectin is accessed via prescription from a licensed health professional, the NIH early this year updated their recommendation to neutral, in that they declared there isn’t sufficient data to recommend for or against. Most regulatory bodies around the world recommend Ivermectin only for clinical trials, and FDA’s advice follows suit.

Was the Arkansas Physician Securing Consent?

Recently, Arkansas Justice of the Peace Eva Madison brought up the issue during a county budget hearing: why was treating doctor Dr. Robert Karas prescribing ivermectin to inmates? Apparently, a county employee also received a prescription from the doctor. Justice Madison was quoted on CNN that to, her surprise, the local sheriff defended the practice of prescribing Ivermectin. Karas has been the provider to Washington County jail since 2015 as a contractor. Karas is on the record defending the use of the Ivermectin, declaring in multiple media interviews including TV station KFSM that he has issued prescriptions to his own family members and “thousands” of others.

Advocate for Early Treatment

A major confrontation emerged between governing health authorities from the NIH, FDA, and CDC which have resisted any positive ivermectin data. Except perhaps for the NIH, who changed their guidance after a meeting with critical care physicians from the Front Line COVID-19 Critical Care Alliance (FLCCC) and Dr. Andrew Hill from the University of Liverpool, from recommend only for clinical trials to a more neutral position. Of course, that could change at any time. Health authorities haven’t authorized any early-stage treatments, yet many treating physicians declare that’s exactly when intervention needs to occur. Dr. Karas emphasized this declaring, “Do you want us to try and fight like we’re at the beaches of Normandy? Or do you want me to tell you what a lot of people do and say — oh, go home and ride it out and go to the ER when your lips turn blue.”

Informed Jail Prescriptions or Something Else?

While jails have become high-risk COVID-19 clusters, most physicians working for corrections won’t use early care treatment, as none are recommended. Yet Dr. Karas does, declaring in the CNN piece that he commenced treatment of the jail’s population with ivermectin as conditions turned bad in November, when he prescribed the drug for “high risk patients over 40.” Defending his practice, he reports no deaths associated with the COVID-19 jail outbreak involving 531 cases. The local Sheriff’s office defended the doctor’s actions, declaring the treatments are voluntary; i.e., they had the patients’ consent. Chief Deputy Jay Cantrell informed the Northwest Arkansas Democrat-Gazette that, “They are able to refuse any medication they’re offered. Even with the vaccine, it’s all voluntary.”

Medical Experimentation?

Now the ACLU gets involved, with accusations reported that the doctor could be involved with medical experimentation. But again, this drug can legally be prescribed off-label as long as the doctor takes adequate measures to inform the patients of the risks, thereby ensuring adequate consent. The ACLU’s claim seems exaggerated, but if the patients are just systematically receiving the drug without any discussion then an issue could be made of this. The medical board in that state is in fact investigating the doctor.

Animal vs. Human Use

Note that many articles report recent cases of poisoning due to people self-treating with veterinary-grade ivermectin. These veterinary drugs are different than the human version, and may not be used safely for self-medication. The FDA rightly warns the public about this, but it does little to clearly distinguish the two distinct types of ivermectin and the fact that it’s perfectly legal to prescribe off-label for COVID-19—at least at this point.

Ivermectin Safety

CNN reported that a CDC health advisory warned of the risks associated with ivermectin use such as, ” gastrointestinal symptoms such as nausea, vomiting, and diarrhea. Overdoses are associated with hypotension and neurologic effects such as decreased consciousness, confusion, hallucinations, seizures, coma, and death.” What they don’t tell you is that the drug has an extraordinarily safe profile, with billions of doses administered over the past few decades. Hundreds of millions of doses are administered annually under the Mectizan program to eradicate river blindness among other parasite-triggered diseases. IS Global in Spain retains expert key opinion leaders who report on the drug’s safety for current indication. But again, the FDA’s point is that they don’t have the same confidence in the existing body of clinical trial results, and thus until some of the bigger studies produce outcomes the agency will remain unconvinced on this topic.

Lots of Research

Presently there have been 63 clinical trials of Ivermectin involving 26,398 patients. Most of the study results have been positive, with a few generating neutral results. These studies are criticized by health authorities and academic commentators in the developed world for not being adequately powered, or lack of quality design, or a number of other critiques. Presently high-profile studies such as University of Minnesota’s COVID-Out and the NIH’s ACTIVE-6 study are investigating the drug in clinical trials.

Call to Action: for an objective fact check (all sides) review TrialSite’s ivermectin fact check.

The CDC reports that ivermectin prescriptions have reached 88,000 per week. During the pre-pandemic period they were 3,600 per week. See the data and graph here:

Rapid Increase in Ivermectin Prescriptions and Reports of Severe Illness Associated with Use of Products Containing Ivermectin to Prevent or Treat COVID-19

HAN Archive - 00449 | Health Alert Network (HAN)

If the medical establishment is trying to suppress the use of ivermectin, or persecute doctors for using it, the establishment is not doing a very good job.

Veterinarians and livestock suppliers report that ivermectin for livestock is widely sold out. Many people are apparently using it to self-medicate. This is a very dangerous thing to do.

I fear that people may be using ivermectin instead of getting a vaccination. This is anecdotal evidence, but I have read news stories describing that. I have a feeling there are many more unreported examples. Here is one of the news stories:

‘He loved his family’: Caleb Wallace dies after battle with COVID-19, pregnant wife says

Caleb Wallace of San Angelo died Saturday after battling COVID for weeks. His wife, Jessica, is due soon with their fourth child and has started a GoFundMe for…

www.gosanangelo.com

This is about a person who campaigned against masks and vaccinations, who died of COVID:

. . . At first, Caleb refused to get tested for COVID-19, or go to the hospital.
"He was so hard-headed," [his wife] Jessica said. "He didn't want to see a doctor, because he didn't want to be part of the statistics with COVID tests."
Caleb instead began taking tablets of ivermectin (an anti-parasitic medicine the U.S. Food and Drug Administration has since urged people not to take for COVID-19), high doses of Vitamin C, zinc aspirin, and an inhaler. By July 30, however, Caleb was taken by a relative to the emergency room at Shannon Medical Center. . . .

It is possible ivermectin works to some extent. I cannot judge. But I am sure that it does not work as well as a vaccine does. So you should not substitute it for a vaccine.

Quote from Shane D.

Politics, and conflicts of interest have made this a particularly hard pandemic to deal with pragmatically as a society. Seemed so simple in the beginning...follow the science, but quickly we discovered politics had infiltrated the health care sciences, it's organizations/institutions -both public and private, that oversee and regulate them, to such an extent that they lost the peoples trust.

We discovered no such thing. You may think so, but you are mistaken about at. The right wing media claims that politics have infiltrated the CDC and other organizations, but that is false. All of their recommendations are in line with what they have said about previous epidemics, and what other public health agencies have said since the mid-19th century. There is no hint of politics in any of this.

The CDC did make some mistakes. Some people interpreted these mistakes as politics. That is incorrect. Scientists, researchers and doctors often make mistakes. The other day someone in the mass media complained that there is politics because the public health agencies will not tell us "the truth, the whole truth, and nothing but the truth." This person did not realize that no one knows the truth in science. You never know "the whole truth;" you don't even know how much whole truth there is left to discover. What is worse, in biology the truth itself keeps changing as the virus mutates. This person was making impossible demands on the scientists.

Quote from Fm1

These veterinary drugs are different than the human version, and may not be used safely for self-medication. The FDA rightly warns the public about this, but it does little to clearly distinguish the two distinct types of ivermectin

That is a peculiar thing to say. It is very easy to distinguish them. The ones intended for livestock say so on the package. There is picture of a cow. On the website (or in the stores now) there is a prominent warning that the product may kill you. Example:

Quote from Fm1

and the fact that it’s perfectly legal to prescribe off-label for COVID-19—at least at this point.

Yes, it is perfectly legal, and it will remain so, because all off-label prescriptions are legal. For that matter, malpractice is usually legal. It is a violation of civil law. Except in extreme cases such as doctors who deliberately amputate limbs for no reason.

Quote from Fm1

Most of the study results have been positive, with a few generating neutral results. These studies are criticized by health authorities and academic commentators in the developed world for not being adequately powered, or lack of quality design, or a number of other critiques.

These criticisms are correct, as far as I can tell. The tests are not adequate, and the designs are poor. I have not read much, but I can see that. It is possible the tests are right despite these problems, but they are weak evidence at best.

Boardmasters festival: New Delta strain believed to have emerged among 53,000 revellers at Cornwall event

New Delta strain believed to have emerged among 53,000 revellers at Boardmasters festival

Almost 5,000 infections have been linked to the Boardmasters festival in Cornwall, and with half a million music lovers at even larger events over the Bank…

inews.co.uk

Fears are rising that a new strain of the Delta variant of Covid-19 has emerged among festival goers after an event attended by 53,000 revellers in Cornwall led to sharp spike in cases among younger people.

With this Bank Holiday weekend witnessing the highest number of music lovers flocking to festivals in 18 months, Public Health England (PHE) is understood to be investigating a possible new Delta strain that may have emerged from the Boardmasters festival in Newquay two weeks ago.

A senior official working on pandemic response in the south-west of England said many of the infections among young people in the region had been identified as coming directly from the festival in Newquay, which now has the highest rate of infection in England at more than 2,000 per 100,000 people.

The source told i: “It was traced because they can identify where it came from by genetic changes in the code.”

While it is being referred to among hospital staff in Devon and Cornwall as the “festival variant”, it is believed to be a new strain of Delta rather than an entirely new variant. Delta already has around a dozen different strains.

“It’s still the Delta variant but they can say it came from the festival, hence why it is being called the ‘festival variant’,” added the official.

The South-west peninsula now home to eight of the top ten areas in England with the highest rates of infection. The figures also show that around half of all infections in England are among those under 30, with the highest rate of infection now in the 10 to 19-year-old age bracket.

Cornwall Council has already linked almost 5,000 Covid infections to Boardmasters, with local health officials saying they “won’t know the complete picture for another few days.”

Public Health England said it had not yet discovered evidence of a new strain linked to Boardmasters, but that any link is being “continually monitored”.

Dr Susan Hopkins, Covid-19 Strategic Response Director at PHE added: “We are consistently reviewing all sequencing data to monitor and assess the emergence of new variants and do this for any surge in cases.”

With around half a million people at music festivals such as those in Reading, Leeds and Let’s Rock Scotland in Edinburgh over the past few days, a senior Government scientific advisor has warned that such mass gatherings offer the virus a far greater opportunity to spread than any other outdoor event type, including at football matches.

Professor John Drury, a member of the Government’s Scientific Pandemic Insights Group on Behaviours (SPI-B) – which is a sub-committee of the Scientific Advisory Group for Emergencies (commonly known as Sage), called on the Government to mandate festival organisers to implement stronger Covid-safe measures to mitigate the spread of the virus.

Speaking in a personal capacity, Professor Drury said: “Different mass events have been found to be associated with very different rates of infection, and one factor explaining this is the crowd culture.

“The [Government’s] Events Research Programme noted that fan behaviour at the Euros was very different than at Wimbledon, for example. And we can expect greater physical intimacy– touching, close interaction, hugging, sharing drinks etc – at a music festival than at other large events.

“One of the key reasons that some people are engaging less with these basic protective behaviours is that the Government has basically said ‘it’s safe now, it’s fine, you’re not going to die’. The problem is of course that 100 people a day are dying. We need to support new norms around safety at the festivals.”

Dr Zubaida Haque, a member of Independent Sage, added: “The thing about mass gatherings is that people are right to think outside is safer than inside, but it’s the travelling back and forth to the mass gatherings that’s one of the main issues. If that mass gathering is for several days, like a music festival, then there’s also going to be a lot more contact between people, which give the virus more opportunity to spread.”

Andrew George, a Cornwall councillor and former Liberal Democrat MP, slammed the Government for “populist headline-chasing above being guided by the science”.

He added: “The fact is the more we have political leaders who prefer to chase favourable headlines, ignore the science and play to the Libertarian right the more we risk creating a more virulent vaccine resistant strain.”

Jayne Kirkham, who is also Cornwall councillor, said: “Many people that went to Boardmasters were 16-29. Very few were double vaccinated, and I don’t know any who went that did not get Covid.

Quote from Shane D.

Unfortunately it can't be used here or in the UK without the prescribing doctor being snitched on by whistle blowers, hounded by the media, and investigated by state medical boards.

That cannot be universally true. As I noted above, there are 88,000 prescriptions per week, and the numbers are increasing rapidly. The medical boards cannot be going after that many doctors. There are not enough boards to do that. As I said, if the establishment is trying to stop ivermectin, it is not doing a good job.

Law enforcement and medical board control over medical abuse is weak, for example in opioid abuse. Granted, ivermectin is a small fraction of opioid prescriptions. There were 2.9 million prescriptions per week in 2019. Some were abusive, and medical boards and law enforcement did go after many doctors, but thousands of other doctors got away with it.

U.S. Opioid Dispensing Rate Maps | Drug Overdose | CDC Injury Center

Quote from ZenoOfElea

"New Zealand has reported what it believes to be its first death linked to the Pfizer Covid-19 vaccine.

An independent vaccine safety monitoring board said the woman's death was "probably" due to myocarditis or inflammation of the heart muscle.

It also noted there were other medical issues which could have "influenced the outcome following vaccination".

European regulators say myocarditis is a "very rare" side effect and that the vaccine's benefits outweigh the risks.

It was bound to happen sooner or later. When you vaccinate more than a billion people, someone is going to die from the effects of the vaccine. If you were to give a teaspoon of salt to a billion people, some number would die soon after from the effects of the salt. Anything can be toxic. See:

A Systematic Review of Fatalities Related to Acute Ingestion of Salt. A Need for Warning Labels?

There are sporadic cases of fatalities from acutely eating salt. Yet, on social media, there are “challenges to” and examples of children and some adults…

www.ncbi.nlm.nih.gov

Quote from Shane D.

When it comes to governmental mitigation mandates and directives, I think the people all over the world (except Aus/NZ) are speaking up and saying "no more lockdowns".

Not true at all. Many older people -- including me -- remain largely self-locked down. I will not go to an indoor restaurant. I am not afraid I might die, but I will not risk feeling crappy for a week with a fever. Been there, done that. It ain't worth risking for a waffle with strawberries. Furthermore, suppose a more virulent form of COVID emerges. Suppose it has a death rate 10 times higher than the present form, with little protection from the present vaccine, and people start dying at the rate of the 1918 influenza. Everyone will voluntarily lock down. I am 100% certain they will. This could happen because so many people refuse to be vaccinated. If it happens, it will be entirely the fault of the right-wing anti-vaxx death cult fanatics and politicians, and people who spread the kind of lies you wrote in the next sentence --

Quote from Shane D.

Masks...the jury is still out.

No, that is not even slightly true. We have known that masks work since the 1880s. That is why doctors and nurses use them. Nothing has changed that fact. What you say here is ignorant, dangerous, anti-science propaganda. Equivalent to saying "it is perfectly okay for people to shit in grocery store isles and on the produce; it cannot hurt anyone." Yes, it is that dangerous.

Quote from Fm1

A prominent team of researchers in China including Prof. Bin Cao, with the National Clinical Research Centre for Respiratory Diseases, China-Japan Friendship Hospital compared 1,276 patients discharged from Wuhan-based Jin-Yin-Tan Hospital during the first phase of the pandemic last year with residents from that city not infected.

Wuhan is not relevant for most CoV-19 victims. The death rate was 90% at that time almost all survivors had severe lung damage. Same happens after severe flu or severe classic corona.

We should focus on new effects only! Like incomplete virus clearing or incomplete spike clearing after gen therapy.

Quote from Fm1

Could AY3 represent the final trigger for more onerous lockdowns to come?

Only ruthless FM/R/X/B mafia members are responsible for lock downs. With Ivermectin the story would be over since one years now. See how to do it: Uttar Pradesh!

Quote from JedRothwell

It is possible ivermectin works to some extent. I cannot judge. But I am sure that it does not work as well as a vaccine does. So you should not substitute it for a vaccine.

In fact Ivermectin works 1000x better than vaccines if given at the right moment. In late stage you should not start self treatment. Best visit a doctor following the I-mask protocol.

Quote from JedRothwell

The ones intended for livestock say so on the package

It's just a matter of money. The human version of Ivermectin is 100x over priced. In fact in Germany the drug store gives you a horse version: Just to remind you. Horses are more delicate than humans and most likely the horse version is better than the human version...

Cat/dog versions are more critical. Check the internet for details!

Quote from Fm1

the UK is no different from the United States, the population has had it with Covid!

The U.S. population is sharply divided on this. The division is by income and political party. Wealthy Democrats are fully on board with public health measures. Poor people from GOP states have "had it" with COVID. They are finished with COVID, but COVID is not finished with them. The infection and death rates are far higher in GOP districts. Health measures are completely different.

In Atlanta, everyone is back to wearing masks. I do not think there is a mandate, but everyone does. In GOP districts, people are harassed for wearing masks. Vaccination levels are 30% to 40%. The hospitals are crammed. As in Florida, stupid people are dying like flies. 100,000 more will die before the end of the year, nearly every one of them preventable. The last I saw the GOP is still fighting to stop masking, vaccinations and vaccine mandates, but Atlanta is Democratic city and we ignore the governor's attempts to undermine public health and kill people.

In Provincetown MA, where the July 4 outbreak alerted the CDC that the delta variant is highly contagious, they have reimposed masking requirements and many bars and other places now demand you show proof of vaccination. See:

After a Midsummer Shiver, Provincetown Proceeds With Care

When the Delta variant came to town, the Broadway stars, drag queens and comics were performing indoors again and the iffy summer of 2020 was just a memory.

www.nytimes.com