The Playground

  • “Even when saving ECMO for the youngest, healthiest and sickest patients, we could only provide it to a fraction of patients who qualified for it,” Gannon said. “I hope these data encourage hospitals and federal authorities to invest in the capacity to provide ECMO to more patients.”

    This is the classic mafia tactics. Cheat the system with no treatment and then propose the most useless but most expensive solution.

    I would not buy one single extra ECMO as this is a waste of money.

  • An Endocrinologist Theorizes the “Key Trigger” for Vaccine-induced Myocarditis


    An Endocrinologist Theorizes the “Key Trigger” for Vaccine-induced Myocarditis
    TrialSite recently was able to engage with Flávio A. Cadegiani, MD, MSc, Ph.D., a board-certified endocrinologist with master and doctorate degrees in
    trialsitenews.com


    TrialSite recently was able to engage with Flávio A. Cadegiani, MD, MSc, Ph.D., a board-certified endocrinologist with master and doctorate degrees in Clinical Endocrinology to learn more about his thoughts on the topic of COVID-19 vaccination and myocarditis.


    Defined as inflammation of the heart muscle, Myocarditis can lead to a weakened heart, heart failure, and sudden death. Symptoms include abnormal heartbeat, chest pain, and shortness of breath. In some cases, myocarditis is the result of the immune system’s response to an infection, or by more systemic inflammatory conditions such as autoimmune disorders. Drugs or other environmental or toxic exposures can lead to myocarditis as well reports Johns Hopkins Medicine.


    Flávio A. Cadegiani, MD, MSc, Ph.D., is a board-certified endocrinologist with master and doctorate degrees in Clinical Endocrinology. Cadegiani is the founder and CEO of the Corpometria Institute where he researches Endocrinology of Physical Activity, and endocrine-related COVID-19 therapies. His special interest in these areas led to a hypothesis regarding the correlation between increased cases of myocarditis in young males, sudden deaths among athletes, and the timing of the mRNA COVID-19 vaccine rollout.


    Cadegiani presents his examination of current literature on the “indisputable complication” of vaccine-induced myocarditis and demonstrates evidence theorizing that catecholamines are triggering heart complications which lead to sudden death in young males.



    What are Catecholamines?

    Catecholamines are hormones that are made by adrenal glands such as dopamine, norepinephrine, and adrenaline. Adrenal glands trigger the production of these hormones when the body experiences physical or emotional stress. This is known as the “fight-or-flight” response. These hormones help the body rev up for action in many ways including enhanced contraction of the cardiac muscle, pupil dilation, increased blood glucose levels, and decreased insulin secretion.


    Rationale and Data that Supports the Hypothesis

    Autopsies


    Cadegiani, (who has also researched the potential risk for developing severe COVID-19 among anabolic steroid users) looked at the findings from three autopsies of young males whose cause of death was determined to be from myocarditis.


    Two adolescents were found dead in their beds a few days after receiving their second doses of the Pfizer/BioNtech mRNA vaccine. The Chief Medical Examiner who assessed the two boys concluded that the damage to their hearts was the cause of “catecholamine-induced myocarditis”–not infection-related myocarditis.


    With infection-myocarditis, the infection causes inflammation that kills the cells. The inflammation is present alongside dead cell groupings known as contraction band necrosis (CBN). However, with catecholamine-myocarditis, CBN can be found without adjacent inflammation. The absence of the inflammation means that a cause other than infection spawned the dead tissue sites. Examples include drug use, toxic exposure, and poisons like snake venom.


    The next autopsy was of a 22-year-old male who died similarly, with the same vaccine, after his second dose. What Cadegiani found “most remarkable” was that the contraction bands identified were “predominantly in the left ventricle, which corresponds to the most demanded area of the heart.” In both reports, the pattern of heart injury for the three deceased were similar to a form of myocarditis that is caused by a catecholamine-producing tumor.


    According to some research the risk of COVID-19 mRNA vaccine-induced myocarditis is 6.6-fold in males 18-29 and 22.3-fold in males 18 and younger.


    The Bridge Between Myocarditis and Sudden Death After mRNA Vaccination


    If mRNA vaccinations trigger the hyperactivity of adrenal gland response, known as a chronic hyperadrenergic state, then it is “plausible,” that this excessive release of adrenaline and noradrenaline, is an “independent predictor of sudden deaths.” Cadegiani evidenced data that the instances of professional soccer players dying suddenly was up 4-fold in 2021, compared to 2009-2020.


    “Adrenal glands have been increasingly demonstrated to be a major site of mRNA SARS-CoV-2 accumulation and SARS-CoV-2 spike protein production, with description of both adrenal cortex and medulla being affected.” The production of adrenal hormones occurs in a progressive manner over time. Could this be why sudden deaths and vaccine-induced cardiac events usually occur after the second vaccine dose?


    Comparing autopsy data from COVID-19 infection and mRNA vaccine deaths, the COVID-19 infections showed more disbursement of RNA throughout various sites, while the vaccine group had more concentration specific to the adrenals.


    Even in a resting state, athletes–particularly male athletes–had significantly higher levels of hormone release in comparison to non-athletes in the same sex, age, and comorbidity groups. Furthermore, adrenal responses were more pronounced in males vs. females.


    Athletes who are already predisposed to the highest levels of adrenal response have even more to contend with after mRNA vaccination. COVID-19 infection and vaccination show similar risks of myocarditis in subjects below 40, but “the risks of heart arrhythmia (irregular heartbeat) were significantly higher,” in the vaccine group. One reason may be that COVID-19 infections are closely monitored, and therefore have a better chance of being detected, while healthy subjects may present asymptomatically post-vaccine.


    Cadegiani’s Final Thoughts

    Cadegiani summarized his six pillars of evidence for the Catecholamine Theory on mRNA SARS-CoV-2 and SARS-CoV-2 Spike Protein-mediated Myocardial Complications:


    The epidemiological findings reveal according to this expert that mRNA vaccines are disproportionately affecting mostly male athletes. Autopsies reveal a clear adrenal-triggered myocarditis in all three cases. SARS-CoV-2 mRNA and the SARS-CoV-2 spike protein accumulate in the adrenal medulla. mRNA increases DOPA-decarboxylase expression that leads to excess noradrenaline production. Younger male athletes naturally have the most elevated catecholamines, and the vaccine seems to exacerbate the adrenal response further.




    In an email interview with TrialSite News, Cadegiani explained that even though “catecholamines may be a key player in the process,” they are “unlikely to be alone, since the rate of myocarditis among patients with pheochromocytoma, a tumor that produces catecholamines, likely has a lower incidence of myocarditis than in (the mRNA) vaccine.”


    “Probably this is a combination of dysfunctional responses and ‘maladaptations’, which are ‘adaptations’ that occur to keep our body functioning, but in a pathological manner that leads to unwanted outcomes.” Cadegiani suspects that “immunological dysfunctions in terms of quality and quantity, combined with dysfunctional hormonal activity, including not only catecholamines, but also androgens (which help understand why these cases are so overrepresented by males), and, possibly, other hormones such as cortisol and thyroid hormones

  • When I was younger, I believed in the "establishment"

    That was foolish of you. You should have read history books. You would have seen that you can sometimes trust the government, but other times you cannot. "The government" is not one entity, entirely trustworthy or not. You can generally trust the Energy Information Agency (EIA.gov), but the plasma fusion division of the DoE is politicized and less trustworthy. How do you know you can trust the EIA? That's simple. Compare their data to industry sources. Use common sense.

    Today I have done a 180, and no longer trust my own government

    That's even more foolish.

    You on the other hand....

    I, on the other hand, have read history and talked to people even as a child, and I have always known that the world is complicated, people are complicated, and things are seldom black and white. I have always been acutely aware of the ambiguity of history. Perhaps because I spent some of my formative years in Japan, going to college in Japanese in the 1970s, when half the population had lived through WWII. I lived not far from Hiroshima. Most middle aged people then, including dear friends of mine, fought in the army or trained to be kamikaze pilots. Some were in Hiroshima when it was bombed, and they had withered limbs. So, although I was very glad the U.S. won the war, I was fully aware of the complexity and the depth of people's feelings, and unspeakable cruelty of the U.S. military response. I think, in retrospect, they might have demonstrated the bomb over Tokyo bay, and they might have delayed dropping the second bomb. Truman wrote in the margin of book about Hiroshima quoting Macbeth, it was "a tale told by an idiot, full of sound and fury, signifying nothing."

  • I'd say this headline is a signal from the government that the pandemic is over!

    Pretty much. Unless a new variant emerges.


    Here is an interesting look back at 2020.


    Masks: Paper shows 2020 mandates reduced spread, but that doesn't mean they are the right policy now
    I have collaborated with a research team at PolicyLab at Children's Hospital of Philadelphia (CHOP) along with University of Pennsylvania that just published…
    www.covid-datascience.com


    Masks: Paper shows 2020 mandates reduced spread, but that doesn't mean they are the right policy now

    I have collaborated with a research team at PolicyLab at Children's Hospital of Philadelphia (CHOP) along with University of Pennsylvania that just published a paper in Health Affairs investigating whether the initial mask mandates in Summer 2020 made an impact local viral transmission and levels.


    In this blog post, I summarize the results of this paper that mask mandates likely

    conferred a benefit in reducing community transmission rates and case incidence during the

    initial months of the COVID-19 pandemic, explain how its motivation was not driven by any political or policy agenda but a desire to learn what the data say, and also explain my personal viewpoint that these demonstrated effects do not imply that mask mandates are the right policy right now, especially for children in schools.

  • Highly divergent white-tailed deer SARS-CoV-2 with potential deer-to-human transmission


    Highly divergent white-tailed deer SARS-CoV-2 with potential deer-to-human transmission
    Wildlife reservoirs of SARS-CoV-2 can lead to viral adaptation and spillback from wildlife to humans ([Oude Munnink et al., 2021][1]). In North America, there…
    www.biorxiv.org


    Summary

    Wildlife reservoirs of SARS-CoV-2 can lead to viral adaptation and spillback from wildlife to humans (Oude Munnink et al., 2021). In North America, there is evidence of spillover of SARS-CoV-2 from humans to white-tailed deer (Odocoileus virginianus), but no evidence of transmission from deer to humans (Hale et al., 2021; Kotwa et al., 2022; Kuchipudi et al., 2021). Through a multidisciplinary research collaboration for SARS-CoV-2 surveillance in Canadian wildlife, we identified a new and highly divergent lineage of SARS-CoV-2. This lineage has 76 consensus mutations including 37 previously associated with non-human animal hosts, 23 of which were not previously reported in deer. There were also mutational signatures of host adaptation under neutral selection. Phylogenetic analysis revealed an epidemiologically linked human case from the same geographic region and sampling period. Together, our findings represent the first evidence of a highly divergent lineage of SARS-CoV-2 in white-tailed deer and of deer-to-human transmission.

  • Liquid metallic hydrogen

    Helium-4 is a liquid at normal pressure near absolute zero, a consequence of its high zero-point energy (ZPE). The ZPE of protons in a dense state is also high, and a decline in the ordering energy (relative to the ZPE) is expected at high pressures. Arguments have been advanced by Neil Ashcroft and others that there is a melting point maximum in compressed hydrogen, but also that there might be a range of densities, at pressures around 400 GPa, where hydrogen would be a liquid metal, even at low temperatures.


    Geng predicted that the ZPE of protons indeed lowers the melting temperature of hydrogen to a minimum of 200–250 K (−73 – −23 °C) at pressures of 500–1,500 GPa (4,900,000–14,800,000 atm; 73,000,000–218,000,000 psi).


    Within this flat region there might be an elemental mesophase intermediate between the liquid and solid state, which could be metastably stabilized down to low temperature and enter a supersolid state.


    Superconductivity

    Main article: Superconductivity

    Further information: Room temperature superconductor

    In 1968, Neil Ashcroft suggested that metallic hydrogen might be a superconductor, up to room temperature (290 K or 17 °C). This hypothesis is based on an expected strong coupling between conduction electrons and lattice vibrations. This may have actually been confirmed as of early 2019, metallic hydrogen has been made at least twice in the laboratory, and a 250K Meissner effect has been tentatively observed but not independently verified by Silvera et al. and a team in France.


    As a rocket propellant

    Metastable metallic hydrogen may have potential as a highly efficient rocket propellant, with a theoretical specific impulse of up to 1700 seconds, although a metastable form suitable for mass-production and conventional high-volume storage may not exist.

  • Low-energy nuclear reaction device for overheat generated by electromagnetic trigger gas and metal and heat production method of low-energy nuclear reaction device (Chinese)

    Free access

    JIN LIHONG / WANG XINGYE / SHEN BINGJUN / TIAN CHENGQI / ZHAO XINLE / ZHOU DAN / LI LINGYU / TIAN ZUOBIN / TIAN JIAN

    2021

    Patent / Electronic Resource

    The invention discloses a low-energy nuclear reaction device for overheat generated by electromagnetic trigger gas and metal . The low-energy nuclear reaction device comprises a vacuum reaction chamber, a gas generator (or a high-purity gas cylinder), a pressure sensor, a temperature sensor, a mechanical pump, a molecular pump, a medium-power power supply, an electric field generator, a rotating magnetic field generator and the like. The process that hydrogen-containing metal generates high-level overheating at specific temperature and pressure under the cooperative use of an electric field generator, a magnetic field generator and the rotating speed of the electric field generator and the magnetic field generator can be achieved, and the invention further discloses a heat generation method. The device is suitable for the technical field of energy, overheating triggering is achieved through the synergistic effect of various means (temperature, pressure, electric field, magnetic field, rotating speed and the like), the problems that in the prior art, the heat production rate is low, the heat production efficiency is low and repeatability is poor are solved, the heat production efficiency of overheating generated by hydrogen gas and hydrogen absorption metal is improved, the heat production rate is increased, the requirement on equipment is reduced, and the reaction process is more convenient to master and control.

  • Activation cross section measurement of the 14N(p ,γ )15O astrophysical key reaction

    Science.gov (United States)

    Gyürky, Gy.; Halász, Z.; Kiss, G. G.; Szücs, T.; Fülöp, Zs.

    2022-02-01 NASA Astrophysics Data System (ADS)

    DOI: 10.1103/PhysRevC.105.L022801 Volume: 105 Issue: 2 Pages: L022801

    Activation cross section measurement of the <SUP>14</SUP>N(p ,γ )<SUP>15</SUP>O astrophysical key reaction
    Background: <SUP>14</SUP>N(p ,γ )<SUP>15</SUP>O is one of the key reactions of nuclear astrophysics, playing a role in various stellar processes and…
    ui.adsabs.harvard.edu


    Background:


    14N(p ,γ )15O is one of the key reactions of nuclear astrophysics, playing a role in various stellar processes and influencing energy generation of stars, stellar evolution, and nucleosynthesis. For a reliable reaction rate calculation, the low-energy cross section of 14N(p ,γ )15O must be known with high accuracy. Owing to the unmeasurable low cross sections, theoretical calculations are unavoidable. Purpose: High-precision experimental cross section data are needed in a wide energy range in order to provide the necessary basis for low-energy extrapolations. In the present work, the total 14N(p ,γ )15O cross section was measured with a method complementary to the available data sets. Method: The cross section was measured with activation, based on the detection of the annihilation radiation following the β+ decay of the reaction product 15O. This method, which provides directly the astrophysically important total cross section, was never used for the 14N(p ,γ )15O cross section measurement in the studied energy range. Results: The nonresonant cross section was measured between 550 and 1400 keV center-of-mass energies with total uncertainty of about 10%. The results were compared with literature data using an R -matrix analysis. It is found that the cross sections measured in this work are in acceptable agreement with the two recent measurements only if the weak transitions—not measured in those works—are included. Conclusions: The present data set, being largely independent from the other available data, can be used to constrain the extrapolated cross sections to astrophysical energies and helps to make the astrophysical model calculations more reliable.

  • Havent' been here in a while because it was getting annoying seeing Freemason or whatever club they are in, members try to swindle use with marketing lines.


    They are still advocating for masks so long after. And the vaccines are now essentially zero efficacy (to negative) in Omicron and adverse events. I got to see vaccine accelerated disease in a family member, not fun stuff.


    People usually have to sell their soul to work this hard! Some people I've found will argue to the end of the earth to support their "side."

    Keep at it W!

  • Pfizer Covid vaccine was just 12% effective against omicron in kids 5 to 11, study finds


    Pfizer Covid vaccine was just 12% effective against omicron in kids 5 to 11, study finds
    New York health officials found the effectiveness of Pfizer's vaccine versus Covid plummeted from 68% to 12% for children ages 5 to 11 during the omicron surge.
    www.cnbc.com


    KEY POINTS

    New York state officials found the effectiveness of Pfizer's vaccine against Covid infection plummeted from 68% to 12% for children aged 5 to 11 during the omicron surge.

    The dramatic drop in vaccine effectiveness was likely due to the lower dosage the youngsters received, according to study team members.

    The data comes as New York City plans to end its school mask mandate by March 7.

  • They still don't understand. It's the sun that controls the virus!!! All VOC have evolved after very active sunspot activity.


    The Emergence of SARS-CoV-2 Variants of Concern Is Driven by Acceleration of the Substitution Rate


    Emergence of SARS-CoV-2 Variants of Concern Is Driven by Acceleration of the Substitution Rate
    Abstract. The ongoing SARS-CoV-2 pandemic has seen an unprecedented amount of rapidly generated genome data. These data have revealed the emergence of lineages
    academic.oup.com


    Abstract

    The ongoing SARS-CoV-2 pandemic has seen an unprecedented amount of rapidly generated genome data. These data have revealed the emergence of lineages with mutations associated to transmissibility and antigenicity, known as variants of concern (VOCs). A striking aspect of VOCs is that many of them involve an unusually large number of defining mutations. Current phylogenetic estimates of the substitution rate of SARS-CoV-2 suggest that its genome accrues around two mutations per month. However, VOCs can have 15 or more defining mutations and it is hypothesized that they emerged over the course of a few months, implying that they must have evolved faster for a period of time. We analyzed genome sequence data from the GISAID database to assess whether the emergence of VOCs can be attributed to changes in the substitution rate of the virus and whether this pattern can be detected at a phylogenetic level using genome data. We fit a range of molecular clock models and assessed their statistical performance. Our analyses indicate that the emergence of VOCs is driven by an episodic increase in the substitution rate of around 4-fold the background phylogenetic rate estimate that may have lasted several weeks or months. These results underscore the importance of monitoring the molecular evolution of the virus as a means of understanding the circumstances under which VOCs may emerge.


    Discussion

    Our mean rate estimates over all lineages are somewhat lower than earlier estimates (Duchene et al. 2020), which is consistent with the notion that the virus has had time to evolve and to remove transient deleterious mutations since its emergence (Ghafari et al. 2022). Clearly, the molecular substitution rate of SARS-CoV-2 displays substantial variation among lineages, a pattern that has been apparent since early phylogenetic analyses of the virus (Duchene et al. 2020).


    Substitution rate variation is sometimes stochastic in nature and pinpointing its causes is often difficult in empirical data. Our explicit hypothesis testing framework suggests that the emergence of VOCs explains much of the substitution rate variation in the virus. This model testing framework has been previously used to understand viral evolution among host species in influenza (Worobey et al. 2014), and the host range SARS-CoV-2 and closely related viruses (MacLean et al. 2021). Here we used marginal likelihood estimators that have shown high accuracy (Fourment et al. 2020), but recent developments, including those based in sequential Monte Carlo (Wang et al. 2020), may improve statistical power for differentiating clock models. We suggest that model testing may be preferable to using highly parametric models, such as relaxed molecular clock models, for this purpose because they tend to have very high variance in substitution rates of particular branches. Recent advances in fitting relaxed and RLC models may provide increased sensitivity and precision in branch specific rate estimates (Douglas et al. 2021; Fisher et al. 2021).


    We find compelling evidence that episodic, instead of long term, increases in the substitution rate underpin the emergence of VOCs, a process that is probably driven the action of natural selection. All models where VOC clades were assigned a different rate to the background had poor statistical fit, even when compared with the SC “null” model, providing further support for such rate increases to occur over a short period of time. The increase in substitution rate required to give rise to the four VOCs examined was estimated to be around 4-fold compared with the background, although such estimates may carry high uncertainty when estimated for individual stem branches. Under these circumstances, the number of mutations required to give rise to a VOC, such as Alpha, would have accumulated in about 3 months, with some variants requiring a few weeks, such as Beta and Delta. These timescales appear plausible in chronic infections of SARS-CoV-2 (Harvey et al. 2021; Kemp et al. 2021), but other circumstances are also likely, for example, if transmission is infrequent and selection favors mutations that increase transmissibility between hosts.


    Our genomic analyses demonstrate that signatures of increased substitution rates are detectable using phylogenetic methods and genome surveillance data. A recent study of reported increased evolutionary rates within sublineages of Gamma (Gräf et al. 2021), which prompts further investigation of within lineage evolution. However, the precise mechanism (ecological or intrahost) of how VOCs have emerged is still unclear. Elucidating these processes will require dense sampling between transmission chains, specifically in settings where transmission is unlikely and intra-host sequence data are available. Another important area that is currently under intense investigation is how natural selection shapes the emergence and persistence of VOCs (Martin et al. 2021; Tegally et al. 2021). Such studies may benefit from using explicit models where the substitution rate is treated as a function of environmental or ecological variables (Streicker et al. 2012). We recommend that further research focuses on early detection and understanding of the circumstances under which viral lineages with epidemiological impacts, such as VOCs, emerge.

  • As most world wide intelligence leaders now believes that Putin is mentally ill, we face at least 2 tough days until he is removed or explodes.


    Putin believes that nobody will touch him, when the nuclear weapons are on highest alert level. This also might include internal enemies...

    All depends now on the lower command level if these folks are willing to eradicate their families.


    Just in case you face the worst:: Have FP95/98 masks ready. Get some iodine pills and bulk some water for at least 7 days.

    Be aware that there will be no internet available and you have to live on your own. Also nobody will tell you what else you can prepare like good shielding cloths from large plastic bags you mount with tape.


    Hope for the best - expect the worst. Old Swiss rule since 150 years...(I'm always fully equipped)

  • India Minister Reveals India Rejected mRNA Vaccines as Companies Wanted Full Indemnity


    India Minister Reveals India Rejected mRNA Vaccines as Companies Wanted Full Indemnity
    While Moderna and Pfizer started negotiating with the Indian government to procure the mRNA-based vaccines during times of intense surges of the
    trialsitenews.com


    While Moderna and Pfizer started negotiating with the Indian government to procure the mRNA-based vaccines during times of intense surges of the SARS-CoV-2 virus, the Indian government never proceeded with a deal. Recently during a book launch authored by Indian health minister Mansukh Mandaviya the prominent official revealed why the mRNA vaccines never were embraced by India.


    In a televised interview Sudhir Chaudhary, the Editor in Chief of WION, an Indian media, inquired as to why India never embraced those two novel COVID-19 vaccines most popular in America and now Europe. After all, in terms of efficacy, at least from a relative risk reduction (RRR) point of view, these were superior vaccines.


    Yet minster Mandaviya declared that both Moderna and Pfizer sought onerous terms involving strict indemnity. The Indian government could only access these potentially lifesaving breakthrough vaccines if they waive all liability should the product cause injury or even death to the Indian people.


    Put another way, severe side effects that led to debilitating (or worse) conditions would not lead to any liability for those companies. As reported in DION “This caused problems for India.” According to the minister, the government didn’t like those terms and thus, decided to proceed with indigenous vaccines of Covishield (AstraZeneca/Oxford licensed to Serum Institute of India) and Covaxin (Bharat Biotech

    In the United States terms under the PREP Act ensures no consumer/patient has any recourse over $50,000 in association with a mRNA-based vaccine injury


    Why were Pfizer and Moderna vaccines not available in India? Health minister responds
    India’s Covid inoculation programme is largely driven by Indian made vaccines. Even though Russia’s Sputnik and Johnson & Johnson's single-dose vaccine were…
    www.wionews.com

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