Covid-19 News

YouTube to Remove All Anti-Vaccine Channels Now in Massive Purge

YouTube to Remove All Anti-Vaccine Channels Now in Massive Purge

As the pace of vaccination decelerates across the country, YouTube undoubtedly feels political pressure from the highest levels of political power.

trialsitenews.com

As the pace of vaccination decelerates across the country, YouTube undoubtedly feels political pressure from the highest levels of political power. Recently, the media provider announced that the video-sharing service owned by Alphabet, Google’s parent company, would block all videos that are deemed associated with anti-vaccine activists, such as Robert F. Kennedy Jr. But are these activists the reason why so much vaccine hesitancy exists?

That would be hard to say, as so much politicization from so many different vantages may confuse the average content viewer in the world of social networks and sites like YouTube. But the edict is clear moving forward—any group that seeks to post material considered anti-vaccine will be yanked. While this policy seemingly applied to COVID-19 vaccines, now the policy expands to any vaccine, such as measles or chickenpox.

Several channels will be removed, from the aforementioned Kennedy’s site to other prominent figures in the anti-vaccine crowd, including Joseph Mercola and Ohio doctor Sherri Tenpenny.

Spike independent replication of human coronavirus in bat cells

Spike independent replication of human coronavirus in bat cells

Bats are a likely zoonotic reservoir for a range of human pathogens including endemic human coronaviruses and SARS-CoV-2. Despite the high burden caused by…

www.biorxiv.org

Abstract

Bats are a likely zoonotic reservoir for a range of human pathogens including endemic human coronaviruses and SARS-CoV-2. Despite the high burden caused by these viruses, the factors required for the establishment and ongoing transmission in humans are not well understood, hampering efforts for pandemic preparedness. To help understand those adaptations required to cross the species barrier, we serially passaged endemic human coronavirus 229E isolates in a newly established Rhinolophus (horseshoe bat) kidney cell line. Here we report extensive mutations, including deletions, in the virus genome that result in the loss of spike protein expression, while maintaining the capability to infect bat cells. While we observed a loss of infectivity of human cells for all viruses with spike deletions, one isolate (2613) with an insertion that results in an early stop codon, was recovered from human cells. Deep sequencing of isolate 2613 showed that the majority population had acquired additional nucleotide insertions in the spike resulting in an additional codon that restores spike function. Spike-independent replication of coronaviruses provides an alternative route for infection of host species that don’t share common cell-entry receptors.

Discussion

To our knowledge this is the first report of active replication of coronaviruses without the required spike receptor binding. The spike gene, especially the RBD is highly variable with multiple insertions and deletions observed24. Spike deletion variants have been documented in fatal human cases of MERS-CoV and SARS-CoV-2 and were attributed to immune driven antibody escape25,26. While some bat sarbecoviruses bind human ACE2, most are unable to engage this receptor due to variation or deletions within the RBD, suggesting alternative receptors or cellular entry pathways27–29. Recent studies have revealed detail of coronavirus replication including the description of large virus-containing vesicles (LVCVs) containing intact30,31 or spike-less virions32, that might help to explain our observed spike-independent virus maintenance in Rhileki cells. Alternative pathways for egress of virions, possibly as part of LVCVs, subsequent attachment and internalization without a strict receptor requirement have also been elucidated33,34.

Combined with the results presented here, this suggests that some coronaviruses may utilize receptor independent membrane fusion. This mechanism may not be found in all bat tissues or species but could help explain features of infection in bats such as low levels of viraemia35 and the dampened immune response to highly pathogenic viruses36. However, it is unlikely that the full spike gene deletions would be present during natural infection as spike binding would obviously increase virus fitness in the presence of the appropriate receptor, and the vast majority of natural spike proteins are full length. Rather, the infection dynamics in Rhileki cells likely favored replication of a shorter viral genome in the absence of other selection pressures present in a natural setting.

Given that alphacoronaviruses can infect a wide range of hosts37, the ability to replicate without requiring the spike protein could provide an alternative route for infection between different bat species, and possibly other hosts, which may not share common receptors. In this scenario, upon transmission to a new host species, infection could be initiated by macropinocytosis of shed virions within LVCVs in urine or stool, but would be significantly increased by acquiring a matching receptor binding protein either from recombination with the host or other coronaviruses. It is therefore critical that we gain a better understanding of the infection biology of host species, particularly the role of LVCVs, involved in the emergence of zoonotic coronaviruses.

Quote from Fm1

YouTube to Remove All Anti-Vaccine Channels Now in Massive Purge

https://trialsitenews.com/yout…els-now-in-massive-purge/

As the pace of vaccination decelerates across the country, YouTube undoubtedly feels political pressure from the highest levels of political power. Recently, the media provider announced that the video-sharing service owned by Alphabet, Google’s parent company, would block all videos that are deemed associated with anti-vaccine activists, such as Robert F. Kennedy Jr. But are these activists the reason why so much vaccine hesitancy exists?

That would be hard to say, as so much politicization from so many different vantages may confuse the average content viewer in the world of social networks and sites like YouTube. But the edict is clear moving forward—any group that seeks to post material considered anti-vaccine will be yanked. While this policy seemingly applied to COVID-19 vaccines, now the policy expands to any vaccine, such as measles or chickenpox.

Several channels will be removed, from the aforementioned Kennedy’s site to other prominent figures in the anti-vaccine crowd, including Joseph Mercola and Ohio doctor Sherri Tenpenny.

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The same story from a different view point - youtube adresses esp. channels and videos spreading obvious fake news ("misinformation").

""This would include content that falsely says that approved vaccines cause autism, cancer or infertility, or that substances in vaccines can track those who receive them," YouTube said, adding that the policy applies to specific immunizations like those for measles, as well as general statements about vaccines"

YouTube is cracking down on anti-vaccine misinformation

YouTube will remove videos spreading misinformation about any approved vaccine, not only those aimed at preventing Covid-19, the company announced in a blog…

edition.cnn.com

Republican Lawmakers Question Attacks on Ivermectin as COVID-19 Treatment

Republican Lawmakers Question Attacks on Ivermectin as COVID-19 Treatment

WASHINGTON–A group of Republican lawmakers threw their support behind doctors who advocate for the use of ivermectin, an inexpensive anti-parasite drug to…

www.theepochtimes.com

WASHINGTON–A group of Republican lawmakers is supporting doctors who advocate for the right to use ivermectin, an inexpensive antiparasitic drug, for treating COVID-19.

Ivermectin is the latest drug caught in controversy after demand surged dramatically in August. Physician and pharmacist groups, including the American Medical Association, “strongly oppose” the prescribing of ivermectin to treat COVID-19 patients. Federal health agencies also issued warnings recently to prevent the use of the drug, stating that “adverse effects associated with ivermectin misuse and overdose are increasing.”

Critical care physician Pierre Kory, however, describes correctly administered ivermectin as “a gift” in the fight against COVID-19.

“I know ivermectin works. I’ve been using it to treat patients for 10 months now,” Kory told The Epoch Times.

During the pandemic, Kory led intensive care units in several hotspots, including New York City. He is one of the founding members of the Front Line COVID-19 Critical Care Alliance, which “strongly recommends” the use of ivermectin in both the prevention and treatment of the virus.

Kory briefed more than 20 members of the conservative House Freedom Caucus on Sept. 27 about the efficacy of the drug.

During the briefing, Kory claimed that ivermectin has helped reduce COVID-19 deaths by 88 percent with early treatment and cases of hospitalization by about 75 percent, based on data from Mexico City and Misiones, a province in Argentina where a large number of patients were treated with ivermectin.

Kory also said COVID-19 cases significantly dropped in Uttar Pradesh, which was the first state in India to introduce large-scale use of ivermectin during the peak of the Delta surge in the country

Sen. Ron Johnson (R-Wis.), who joined the briefing, criticized the efforts to quash access to the drug as a treatment for COVID-19. Johnson has been a vocal advocate for COVID-19 treatments beyond vaccines, including ivermectin. A possible explanation for the resistance “has to do with money,” he told The Epoch Times.

“The vaccine has been worth billions to these companies. Is that what’s driving this? I would like to think that’s not the case,” he said. “How many lives could have been saved had our federal health agencies robustly explored all these generic drugs?”

Ivermectin is an FDA-approved antiparasitic drug that has been used safely for more than three decades in the treatment of certain worm infections. The two doctors who developed ivermectin received the Nobel Prize for Medicine in 2015 “for improving the health and wellbeing of millions of individuals with River Blindness and Lymphatic Filariasis, primarily in the poorest regions of the world.”

While ivermectin wasn’t developed to treat viruses, an increasing number of doctors around the world believe in the efficacy of the drug against COVID-19.

More than 88,000 ivermectin prescriptions were reported in the United States in the second week of August, which is 24 times higher than the pre-pandemic level, according to the U.S. Centers for Disease Control and Prevention (CDC). The Food and Drug Administration (FDA) published an article warning against the use of the drug, stating that many have been taking a medicine intended for animals.

“You are not a horse. You are not a cow. Seriously, y’all. Stop it,” the agency posted on Twitter on Aug. 21.

Rep. Louie Gohmert (R-Texas), a member of the Freedom Caucus and one of the supporters of allowing people the right to try ivermectin, criticized federal agencies and the media for smearing the drug as a “horse treatment.”

In an interview with The Epoch Times, Gohmert called the efforts to suppress the use of ivermectin as “dishonesty,” which is preventing people from having access to an FDA-approved drug that is inexpensive and widely available. He likened these efforts to the disinformation tactics used for decades by the tobacco industry to dismiss the health risks of smoking.

“It goes beyond being wrong. It gets virtually to being criminal,” Gohmert said.

The FDA warned that it hasn’t yet approved ivermectin “for use in preventing or treating COVID-19.” The agency stated that the “currently available data do not show ivermectin is effective” against the virus, adding that the clinical trials are ongoing.

According to Kory, FDA approval for ivermectin use to treat COVID-19 isn’t required for off-label prescriptions. Off-label use refers to using an approved drug to treat a different type of disease that the drug isn’t approved to treat. Nearly 20 percent of all prescriptions written in the United States are off-label.

There are now threats from medical boards to take away licenses from doctors who prescribe ivermectin, Kory said.

“I cannot describe the harm, and the tragedy, and the actual humanitarian crisis that this is causing,” he said.

NTD reporter Steve Lance contributed to this report

Quote from Wyttenbach

So I cannot understand why the younger want a jab just to get a new fake freedom that ends after 6 months.

Nobody in my family wanted the Prick. My wife got it only because her work mandated it, and my son got it only because his school mandated it. Both waited until the last minute, in the vain hope that the mandates would be reversed, but no.

Quote from Fm1

Feeling little responsibility to protect all workers during COVID-19 and demonstrating their willingness to sacrifice unvaccinated workers for the perceived greater good, these uncaring employers should be held accountable for violating Canada’s immunization policy and disrespecting the Canadian Constitution.

This shows that our constitution and policies are mere fair-weather songs in the breeze. Not too long ago Trudeau and the provincial premiers were saying they would never invoke vaccine passports and mandates. Now of course they have done a 180, and Federal and provincial employees are mandated to get Shot, and now most post secondary schools and larger businesses are doing the same in the name of workplace safety.

Quote from Wyttenbach

This is very odd. No healthy person age <30 ever die of CoV-19. Frequent Long-Covid among kids is just a fake invention of big pharma marketing. So I cannot understand why the younger want a jab just to get a new fake freedom that ends after 6 months.

People are just nuts I believe. Flu is much more deadly for most younger people!!

Glad that you have gone from healthy < 65 not at risk to healthy <30 not at risk! Progress.

In addition to what Alan says, you might want to note that long COVID remains a risk for all ages. New study:

News: First findings from world’s largest study on long COVID in children and young people | NIHR

Up to one in seven children and young people who had COVID-19 may have symptoms linked to the virus 15 weeks later, suggest preliminary findings from the world’s largest study on long COVID in children and young people.

For the study, published on the preprint site Research Square and funded by the NIHR and UK Research and Innovation (UKRI), researchers surveyed 3,065 11- to 17-year-olds in England who tested positive for SARS-CoV-2 in a PCR test between January and March. They were paired with a matched control group of 3,739 11- to 17-year-olds who tested negative over the same period.

The researchers found that, when surveyed at an average of 15 weeks after their test, 14% (one in seven) more young people in the test positive group had three or more symptoms of ill health, including unusual tiredness and headaches, than those in the test negative group, while 7% (one in 14) more had five or more symptoms.

Lead author Professor Sir Terence Stephenson, from UCL Great Ormond Street Institute of Child Health, said: “There is consistent evidence that some teenagers will have persisting symptoms after testing positive for SARS-CoV-2. Our study supports this evidence, with headaches and unusual tiredness the most common complaints.

I'm still baffled by W's statements about healthy younger people not being at risk. The age dependence of risk is very clear, but while increased risk for those who have comorbidities is real, it is only around X2 or so, equivalent to 6 years. Less of the younger population are unhealthy, so the risk benefit for this relative to average decreases.

I think it is an emotional thing where the idea that if you are healthy enough you are not vulnerable must be attractive.

Quote from Mark U

Nobody in my family wanted the Prick. My wife got it only because her work mandated it, and my son got it only because his school mandated it.

Such homogeneity of an outlying opinion in one family grouping is maybe of interest, perhaps we should look at some sociological studies of why anti-vax sentiment tends to run in families.

I blame social media

Quote from THHuxleynew

Such homogeneity of an outlying opinion in one family grouping is maybe of interest, perhaps we should look at some sociological studies of why anti-vax sentiment tends to run in families.

I blame social media

I blame the parents

Quote from Mark U

However about six hours later she was starting to shiver. Soon she was fevered. Very hot to the touch. She doesn't think she slept at all that night, and I can attest to that. Her breathing all night was laboured, fast and shallow. Her head hurt. Her eyes hurt. Her ribs hurt. Her energy was gone. Finally, after a day an a half of convalescing and suffering, her fever broke, and her blankets were wet with sweat. Thankfully she had Monday off work so she could more fully recover. This is a lady who has never taken a day off work sick that I recall. I've never seen her so sick.

She wasn't sick this time either. On the contrary, a strong reaction is a sign of good health. It is normal. Nothing to worry about. My wife, who is also very healthy, had a strong reaction to the COVID and hepatitis vaccines.

You should not complain about this. It is MUCH better than a serious bout of COVID, and incomparably better than dying from COVID.

Quote from Mark U

I can see how this vaccine could take out those with an already compromised constitution.

By "take out" do you mean kill them? That has never happened. Billions of doses have been given, and that has not happened even once. So you are saying that you can "see" how something has never happened and will never happen might happen. You must be hallucinating.

Norway and Singapore lift Covid

Restrictions.

Does the World Medical Association Want to Shut Down Free Speech?

Does the World Medical Association Want to Shut Down Free Speech?

The World Medical Association (WMA) is an international body that represents doctors, and it was founded in 1947 by practitioners from 27 nations. Its

trialsitenews.com

The World Medical Association (WMA) is an international body that represents doctors, and it was founded in 1947 by practitioners from 27 nations. Its goals were to “ensure the independence of physicians” while advocating for “the highest possible standards of ethical behavior and care by physicians, at all times.” This focus on ethics was decided upon in the aftermath of World War II and in the shadow of the gruesome conflation of experiments and torture during the Nazi regime. As a side note, the Nazis took much of their philosophy from early American eugenicists, and, e.g., nonconsensual sterilization of “undesirables” took place in the US for decades. WMA is really an association of associations, and its direct members are 115 separate national medical associations. WMA purports to be “a forum for its member associations to communicate freely, to co-operate actively, to achieve consensus on high standards of medical ethics and professional competence, and to promote the professional freedom of physicians worldwide.” The organization helps guide policy for medical groups worldwide and offers declarations and resolutions, including the International Code of Medical Ethics. WMA claims that they promote and defend the “basic rights of patients and physicians.” In a bit of vagueness, WMA says without detail that it “is in official relations with the [WHO].”

A Modernized Version

The International Code of Medical Ethics was first adopted in London in 1949 and has been amended three times since then. The current version includes many positive provisions that help empower doctors and patients. The Code states that doctors shall “always exercise his/her independent professional judgment and maintain the highest standards of professional conduct,” that patients can refuse treatment, that doctors should act in the patient’s best interest, and many other commonsense yet important duties. On May 3, 2021, WMA announced that they were taking comments on proposed revisions to the Code. The goal is a “modernized” version, and new clauses deal with “physicians’ potential conflicts of interest, advertising, telemedicine and duties towards the environment.” Importantly, the Code adds a clause for health inequality amelioration. In an April discussion, the WMA published the proposed new Code. While some of the changes are muted; e.g., doctors were to use “due caution” in discussing new scientific developments with the public, they are now to do so in a “prudent” fashion. But two new provisions may, in fact, wrongly hamper doctors’ and patients’ rights under the First Amendment. In Rule 35, they note, “Physicians should be especially careful to distinguish in their public comments between evidence-based scientific information and their personal opinions.” And in Rule 36, they posit that “Physicians should avoid acting in such a way as to weaken public trust in the medical profession.”

Two New Rules Ill Advised

From TrialSite’s perspective, these new rules are problematic. What if the medical profession is doing something wrong? Can a doctor never say that this is happening? And doctors’ opinions are not totally distinguishable from evidence-based medicine, so that rule appears designed to shut down free speech in the medical community. Without the free exchange of information, progress in science is impossible. We vote “no” on the proposed new Code.

WMA - The World Medical Association-Home

WMA - The World Medical Association-WMA International Code of Medical Ethics

WMA - The World Medical Association-Physicians Code of Ethics Updated

Quote from Alan Smith

the Joint Committee on Vaccination and Immunisation (JCVI), found that “six (24%) of the 25 [children and young people under 18] who died of SARS-CoV-2 appeared to have no underlying health conditions.”

We reported this (unknown death cause for 6 UK children) already a month ago. The people reporting these deaths did simply not do any lookup. Unless a section is done nobody knows the details.

Also children have a death rate. CoV-19 is by far the least contribution. From people doing the lookup we know its 0 for Switzerland and USA. But this can change tomorrow...

Most places did see a RSV pandemic due to masking children... So may be some doctors just opted for the higher pay check...

Quote from zorud

The same story from a different view point - youtube adresses esp. channels and videos spreading obvious fake news ("misinformation").

The problem is who decides? Big pharma marketing or fact based research.

Just one sample: The girls pappiloma vaccine caused a lot of damage in Japan. So Japan has stopped teh highly damaging vaccine. Japanese have a special gene pool and most drugs would need a proper test for this gen pool. But Big pharma marketing does not like this.

What would google (aka big pharma) do? Ban Japanese state information?

Quote from Mark U

Nobody in my family wanted the Prick. My wife got it only because her work mandated it, and my son got it only because his school mandated it. Both waited until the last minute, in the vain hope that the mandates would be reversed, but no.

It is sad to live in vaccine terror state. I hope your son will recover. May be one day somebody will XXXXXX the school...

Quote from THHuxleynew

I think it is an emotional thing where the idea that if you are healthy enough you are not vulnerable must be attractive.

Clever people know how to treat CoV-19. Dumb ones produce day & night FUD.

We eagerly wait for your ONS data adjustment for the age group 40..50. Selective dementia?

Quote from THHuxleynew

In addition to what Alan says, you might want to note that long COVID remains a risk for all ages. New study:

A Swiss study did show that there is no long Covid among children. Also the UK study finds that PCR+ children overall have 10% less symptoms than the negative ones. The questionary return rate was 13%. This point to a huge bias. Also for doing a serious study you cannot send younger people a questionary. Only interviews are allowed. Just throw it to the bin.

Any infection may lead to long term health issues. And guess how severe this will be in a vaccine terror state that delivers daily mind blowing fear monger news...

Quote from THHuxleynew

perhaps we should look at some sociological studies of why anti-vax sentiment tends to run in families.

One more racist is outing here...

Quote from JedRothwell

She wasn't sick this time either. On the contrary, a strong reaction is a sign of good health. It is normal.

Tell this the parents at funeral time...

Quote from Fm1

And in Rule 36, they posit that “Physicians should avoid acting in such a way as to weaken public trust in the medical profession.”

No whistle blowing allowed...Only cheat (suck out) the patients...

CDC Booster Safety Updates

CDC Booster Safety Updates

New data from the U.S. Centers for Disease Control and Prevention (CDC) “Morbidity and Mortality Weekly Report” involve 12,600 people who after receiving

trialsitenews.com

New data from the U.S. Centers for Disease Control and Prevention (CDC) “Morbidity and Mortality Weekly Report” involve 12,600 people who after receiving an initial mRNA COVID-19 vaccine or Pfizer booster shot reporting on their side effects. They did so by using the voluntary V-Safe CDC survey accomplished via smartphone between August 12, 2021, and September 19, 2021.

According to the CDC data, the most common impacts associated with the booster shots include the following:

Reported Side Effect Amount

Pain, at the injection site 66.6% (3 doses of Pfizer) 75.9% (3 doses Moderna)

Fatigue 51% (Pfizer) 61.8% (Moderna)

Headache 38.4% (Pfizer) 49%.8% (Moderna)

Joint Pain 23% (Pfizer) 33% (Moderna)

Fever 22.2% (Pfizer) 36.4% (Moderna)

Note, less common side effects associated with the third booster include chills, inflammation at the jab site, stomach ache/nausea, diarrhea, rash, and redness at the jab site.  What about severe effects. ? Nearly a quarter of the Pfizer booster shots led to severe enough side effects leading to a lack of ability to perform daily routine (e.g., not going to work), while that number was just over a third for Moderna. These figures were slightly better than the severe response after the second shot.

Some suggest the booster program chatter dilutes attention from the core effort

According to the CDC report, the research team implies that side effects associated with the third booster are comparable to those experienced after the second jab.  This implies that there aren’t any surprises to anticipate for the third jab.

Other data from around the world

TrialSite offers data from around the world, and it’s not all rosy regarding a third booster.  A German physician’s society, the Medical Association of North Rhine Ärztekammer Nordrhein (aekno.de),  sent a letter to their members informing them about an incident in a nursing home where 90 residents were administered the third booster shot that led to some problems.  Apparently, one death occurred as well as two resuscitations and nine critically ill elderly recipients with cardiopulmonary symptoms apparently in association with the third jab.

German authorities nor the European Medicines Agency had authorized the use of the booster hence this one association urged its members to reconsider the need for the booster at least at this point.

Meanwhile, in another reported incident at a 136-bed Canadian nursing home, TrialSite sources shared that there were adverse events associated with a booster program recently.  According to anonymous sources, at least seven adverse events were reported along with four deaths. However, TrialSite cannot verify these claims involving Sunnycrest Nursing Home in Whitby Ontario.

Official U.S. Government Report

CDC reports for the period cover indicate no red flags or serious risk indicators. TrialSite will continue to monitor the situation.

Ärztekammer Nordrhein

Gesundheitsinformationen für Ärzte und Bürger, eine Datenbank mit über 900 Selbsthilfegruppen, Arzneimittelinformationen und das Wichtigste aus der

www.aekno.de

Safety Monitoring of an Additional Dose...

This report describes local and systemic reactions reported after a third dose of COVID-19 vaccination compared to after the second dose.

www.cdc.gov

Biden Administration Usurpation of Monoclonal Antibody Supply Chain Endangering COVID-19 Patients

Biden Administration Usurpation of Monoclonal Antibody Supply Chain Endangering COVID-19 Patients

While the federal government has systematically blocked any physician-initiated, off-label approaches to treating COVID-19 (e.g., ivermectin, etc.), a

trialsitenews.com

While the federal government has systematically blocked any physician-initiated, off-label approaches to treating COVID-19 (e.g., ivermectin, etc.), a disturbing trend emerges with the only treatment class available. These include the monoclonal antibody products currently authorized under emergency use. These investigational therapies are in demand, but since the federal government intervened in the allocation and supply chain, a terrible situation mounts as reports of shortages materialize across the country. As TrialSite reported, the State of Florida via Gov. DeSantis established an aggressive care delivery program that appeared to work until over 50% of the therapeutic supply was cut by the Biden administration as part of a federal rationing program. Now reports from around the country don’t improve confidence levels in the current administration’s commitment to COVID-19 care. Most recently, COVID-19 patients in Anchorage, Alaska, are rejected care at a dire time.

POTUS Control

Recently, under the Biden administration, the federal government took control of the allocation and supply of monoclonal antibodies via the Department of Health and Human Services (HHS) rather than allowing individual sites to order products themselves. Florida’s Gov. Ron DeSantis warned at a press conference that this move by the feds would trigger severe disruptions. DeSantis declared, “We are very, very concerned with the Biden administration and HHS’s recent abrupt, sudden announcement that they are going to dramatically cut the number of monoclonal antibodies that are going to be sent to the state of Florida.” On September 23, DeSantis called on the Biden administration to restore the supply of product so the state could care for more patients.

TrialSite reported recently on the dire consequences of that action, as over 50% of the supply was cut during the worst possible time.

Limited Product & Even More Limited Government

A few monoclonal antibody treatments have been authorized on an emergency basis, including Regeneron, GSK/Vir Biotechnology, and most recently, Lilly in combination with Junshi Biosciences for post-exposure prophylaxis for high-risk individuals.

But delays in the supply chain are palpable—and becoming outright dangerous for those patients in need of urgent care. For example, the Anchorage Daily News reports that 110 COVID-19 patients in Anchorage were turned away for treatment at a treatment facility. The Tikahtnu Common treatment manager Jyll Green reported, “It’s really depressing” as nurses were sent home with no monoclonal therapy doses available to administer and no expectation of when the shipment will arrive.

The demand and supply scenarios are out of whack as the supply chain is overwhelmed, reports a Coleman Cutchins pharmacist in Alaska.

Delays are surfacing everywhere. For example, in Oklahoma, clinics report that their supplies of monoclonal antibodies have also been slashed (much like Florida), hurting patients needing urgent care. For example, the COVID Treatment Infusion Center in Moore, OK, typically administers 250-300 monoclonal antibody treatments a week, but according to Jessica Deppen, in the last couple weeks, they only received 96 vials. State Rep. Jon Echols reported last week that hospital CEOs and clinics around the metro area report a troubling lack of supply since the government usurped the allocation process. According to Rep. Echols, “The feds took something that was working and made it worse. They need to stop, get out and make it more available.”

In Oklahoma, the Oklahoma State Department of Health (OSDH) was authorized to determine the supply and demand needs of the state. However, Elce Holloway, OSDH state hospital preparedness program coordinator, reported demand for the treatment is not aligning with what is being requested.” While Oklahoma orders 9,000 doses per week, only 2,000 to 2,500 are being allocated. As reported by News On 6 in Tulsa now, clinics are instructed to triage patients.

Meanwhile, the same problem surfaces in San Diego County, according to local media NBC San Diego as severe limits on monoclonal antibody supply surface in California. Dr. Christian Ramers with Family Health Centers of San Diego reports, “On a national level, it’s been devastating.” Dr. Ramers continued, “In my own clinic, we now are told that we have barely a week’s supply. People that don’t want to get a vaccine are surprisingly embracing this, even though this is an experimental, not FDA approved with no long-term data. People, once they get sick, they want something really effective.”

TrialSite summarizes that while the southern states have been hit hardest by the Delta variant-based surge, the extensive dependence on monoclonal antibodies was disrupted by government-based rationing. With surges across even heavily vaccinated states, the demand for monoclonal antibodies outstrips the supply, and patients everywhere are paying the price.

Race to Capture $10b COVID-19 Orally Administered Antiviral Market is On

Race to Capture $10b COVID-19 Orally Administered Antiviral Market is On

The race to develop antivirals targeting COVID-19 intensifies with approximately $10 billion per annum at stake. Leaders in the race include Pfizer,

trialsitenews.com

The race to develop antivirals targeting COVID-19 intensifies with approximately $10 billion per annum at stake. Leaders in the race include Pfizer, Merck, and Roche. At the same time, generic off-label options such as physician prescribed ivermectin are under heavy attack by a confluence of government agencies, industry, academia, and the press. TrialSite suggests that the market must be cleared of any generic competition to fully monetize the COVID-19 pandemic. Other biotech and pharmaceutical companies pursue this market, including Enanta Pharmaceuticals (ENTA.O), Padres Biosciences, Shionogi & Co Ltd (4507.T), Novartis AG, and several others. Presently, only intravenous (remdesivir) and monoclonal antibodies administered via infusion are approved or authorized on an emergency basis.

While the dominant chatter remains that the best way to control the pandemic is using vaccines, the reality is that antivirals represent explosive demand. Already, the demand for monoclonal antibodies far outstrips supply, as reported by TrialSite recently.

TrialSite’s founder Daniel O’Connor shared, “For over a year now, we at TrialSite have argued that oral antiviral medication used at infection onset represents an absolutely vital tool in the war against COVID-19.” He continued, “The vast majority of COVID-19 cases are mild-to-moderate in nature, and if a safe and effective orally administered treatment is available to reduce infection progression that combined with vaccination and other smart public health measures can help society leave the pandemic behind.” On the topic of repurposed off-label use of Ivermectin, O’Connor shared, “We have spoken with hundreds of doctors and researchers around the world that have seen ivermectin help along with other treatments to inhibit infection progression, but we believe the undeniably orchestrated attack on the drug by mainstream media will clear the market out for full-throttle monetization by the pharma industry.”

What follows is a breakdown of some of the COVID-19 antiviral drugs in the pipeline.

Antiviral Target for EUA or Approval Class/Description

Merck (Molnupiravir) Possibly by end of year Novel Broad–Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2

Roche (AT-527) Possibly end of year Polymerase inhibitor

Pfizer (PF-07321332) Possibly end of year or early Q1 2022 protease inhibitors

Pardes ( PBI-0451) Mid to late 2022 protease inhibitors

Shionogi (S-217622) Large-scale trials end of 2021 3CL protest inhibitor

Enanta (EDP-235) Start human trials early 2022 Protease Inhibitor

Novartis (MP0420) Mid-2022 Novel tri specific DARPin candidate

Sorrento Therapeutics (MP18) Late 2022 Oral antiviral MPro inhibitor

Numerous other therapies including nasal sprays are under development. TrialSite’s Investor Watch is available for specific research requests.

COVID-19 pill developers aim to top Merck, Pfizer efforts

As Merck & Co and Pfizer Inc prepare to report clinical trial results for experimental COVID-19 antiviral pills, rivals are lining up with what they hope will…

www.reuters.com

Quote from Fm1

Race to Capture $10b COVID-19 Orally Administered Antiviral Market is On

https://trialsitenews.com/race…d-antiviral-market-is-on/

The race to develop antivirals targeting COVID-19 intensifies with approximately $10 billion per annum at stake. Leaders in the race include Pfizer, Merck, and Roche. At the same time, generic off-label options such as physician prescribed ivermectin are under heavy attack by a confluence of government agencies, industry, academia, and the press. TrialSite suggests that the market must be cleared of any generic competition to fully monetize the COVID-19 pandemic. Other biotech and pharmaceutical companies pursue this market, including Enanta Pharmaceuticals (ENTA.O), Padres Biosciences, Shionogi & Co Ltd (4507.T), Novartis AG, and several others. Presently, only intravenous (remdesivir) and monoclonal antibodies administered via infusion are approved or authorized on an emergency basis.

While the dominant chatter remains that the best way to control the pandemic is using vaccines, the reality is that antivirals represent explosive demand. Already, the demand for monoclonal antibodies far outstrips supply, as reported by TrialSite recently.

TrialSite’s founder Daniel O’Connor shared, “For over a year now, we at TrialSite have argued that oral antiviral medication used at infection onset represents an absolutely vital tool in the war against COVID-19.” He continued, “The vast majority of COVID-19 cases are mild-to-moderate in nature, and if a safe and effective orally administered treatment is available to reduce infection progression that combined with vaccination and other smart public health measures can help society leave the pandemic behind.” On the topic of repurposed off-label use of Ivermectin, O’Connor shared, “We have spoken with hundreds of doctors and researchers around the world that have seen ivermectin help along with other treatments to inhibit infection progression, but we believe the undeniably orchestrated attack on the drug by mainstream media will clear the market out for full-throttle monetization by the pharma industry.”

What follows is a breakdown of some of the COVID-19 antiviral drugs in the pipeline.

Antiviral Target for EUA or Approval Class/Description

Merck (Molnupiravir) Possibly by end of year Novel Broad–Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2

Roche (AT-527) Possibly end of year Polymerase inhibitor

Pfizer (PF-07321332) Possibly end of year or early Q1 2022 protease inhibitors

Pardes ( PBI-0451) Mid to late 2022 protease inhibitors

Shionogi (S-217622) Large-scale trials end of 2021 3CL protest inhibitor

Enanta (EDP-235) Start human trials early 2022 Protease Inhibitor

Novartis (MP0420) Mid-2022 Novel tri specific DARPin candidate

Sorrento Therapeutics (MP18) Late 2022 Oral antiviral MPro inhibitor

Numerous other therapies including nasal sprays are under development. TrialSite’s Investor Watch is available for specific research requests.

https://www.reuters.com/busine…fizer-efforts-2021-09-28/

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Only an army of Towne Criers and FM agents could gaslight people enough to make even physicians confused that antivirals don't work (like HCQ) for 1.5 years and now suddenly a huge spectrum of antivirals are being invented within 1.5 years!

They love deception, they are very happy they have confused you!