The Playground

    When will Schrodinger's cat catch ROSSi's Schrodinger's MOUSE? Oh he has already caught it using a BALLAST in the blue box to power his run-down 'ballerina' Hg LAMP! The spectra he showed for the SK was fudged. But then again being a mafia boss he probably likes only the best quality sucrose. Well done Leonardo!

    Again this is terribly 'con' fusing - not only do we have trans-sexual human rights to fight for, now we have trans-human rights which are a cobbled together mixture of economics and eugenics! But as the economics wizard Patrick Woods points out most changes made in this scientific field have had largely NEGATIVE RESULTS! MAYBE THIS IS A STRONG MESSAGE TO LEAVE NATURE ALONE, ie let human, animal and plant evolution continue with the usual chaotic mandelbrot pattern.

    Ayurvedic compound may serve as ‘starting point’ for COVID-19 treatment

    Azadirachta indica A. Juss bark extract and its Nimbin isomers restrict β-coronaviral infection and replication


    https://www.sciencedirect.com/…2682222000022?via%3Dihub#!


    Highlights

    •

    What is already known:

    i.

    Azadirachta indica bark extract restricts HSV-1 and murine-β-Coronavirus replication, spread, and fusion in vitro.

    ii.

    m-CoV-MHV-A59/RSA59 when preincubated with Azadirachta indica bark extract (NBE) restricts viral infectivity in vivo.

    •

    What this study adds:

    i.

    NBE significantly restricts newly emerged human β-Coronavirus SARS-CoV-2 infection and replication in vitro.


    ii.

    Nimbin/Epinimbin significantly inhibits m-CoV-infectivity, cell-to-cell fusion, spread, and replication in vitro like NBE.

    •

    Clinical significance:

    i.

    NBE/it's isolated Nimbin/Epinimbin isomers significantly reduces coronaviral-induced clinical outcome, acute and chronic inflammatory pathology.

    ii.

    The Triterpenoids compounds of NBE inhibit SARS-CoV-2, HSV-1 and m-CoV infectivity, suggesting pan-β-anti-coronaviral/pan-antivirals.


    Abstract

    Emerging mutations in the SARS-CoV-2 genome pose a challenge for vaccine development and antiviral therapy. The antiviral efficacy of Azadirachta indica bark extract (NBE) was assessed against SARS-CoV-2 and m-CoV-RSA59 infection. Effects of in vivo intranasal or oral NBE administration on viral load, inflammatory response, and histopathological changes were assessed in m-CoV-RSA59-infection. NBE administered inhibits SARS-CoV-2 and m-CoV-RSA59 infection and replication in vitro, reducing Envelope and Nucleocapsid gene expression. NBE ameliorates neuroinflammation and hepatitis in vivo by restricting viral replication and spread. Isolated fractions of NBE enriched in Nimbin isomers shows potent inhibition of m-CoV-RSA59 infection in vitro. In silico studies revealed that NBE could target Spike and RdRp of m-CoV and SARS-CoV-2 with high affinity. NBE has a triterpenoids origin that may allow them to competitively target panoply of viral proteins to inhibit mouse and different strains of human coronavirus infections, suggesting its potential as an antiviral against pan-β-Coronaviruses.

    Quote from Dr Richard*

    now we have trans-human rights which are a cobbled together mixture of economics and eugenics!

    I do not know anything about how transhuman rights have been formulated lately, but I gather they apply to any sentient being. Including, for example, other primates. I am strongly in favor of granting other primates rights, especially the right to have living space and to remain unmolested by people. Primates are much smarter than most people realize, and they have deep feelings. When a baby chimpanzee dies, the mother is often seen to grieve for weeks. She may carry the dead baby. She may not eat or interact with others. Furthermore, as you see in this video of a baby orangutan, it has:


    A sense of object permanence;
    It understands human intentions;
    It has a sense of humor. Which is a lot like my sense of humor.


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    By AR's history when he says 3, he means 3 E-cats.

    Sam. how do you expect Rossi to get all the chips he needs for the "AI" during this chip shortage?

    One more Ukraine reminder::


    Daddy Biden still did not block almost all of Putin money. Putin's money follows the same chain as all the the > 5'000'000'000'000$ that over the last few years went into to complex Blackrock funds, that are held by at least a 3 layer architecture.


    All the money entered USA over Delaware --> Cayman/Bermudas and comes back into multiple funds of funds. So the entry point and end point (black rock fonds) is in USA.


    So the top of the Ukraine war is in the USA.


    According international law the Ukraine as a sovereign state and can always ask other countries for direct military help. If the Ukraine e.g. proclamates a no fly zone e.g. over western Ukraine this is not WW III this is top fake news from Biden even if the USA helps to install this zone. It's the decision of Ukraine to have it.


    The US FM/R/J/B mafia simply did agree to this war.

    Quote from PhysicsForDummies

    By AR's history when he says 3, he means 3 E-cats.

    Sam. how do you expect Rossi to get all the chips he needs for the "AI" during this chip shortage?

    I asked him a while back.

    I hope he gets enough so the

    Allan Smiths of the World can

    get a ECatSKLep and test them.


    2021-10-29 12:22 Sam 

    Hello DR Rossi

    Are you concerned with the

    Global Chip Shortage with

    your Products.

    Cisco CEO Robbins on global chip shortage: We have a ways to go
    Cisco chairman and CEO Chuck Robbins joins 'Squawk Box' to weigh in on the global semiconductor chip shortage. To see the full interview with Robbins sign up...
    youtu.be

    Regards

    Sam

    2021-10-30 02:30 Andrea Rossi 

    Sam:

    Yes, but it should not affect us.

    Warm Regards,

    A.R.

    Quote from Alan Fletcher

    He has previously said you can't do that.

    Hmmm, I don't recall Rossi saying it can't be done. For instance,


    2021-12-10 15:54 Don Z

    Congratulations on the Ecat SKLep. To me it seems that your 100W Ecat SKLep would be equivalent to a 300W stationary solar panel, assuming it averages only 8 hours of usable sunlight a day.

    I am looking at an off grid cabin situation.

    1. Can you connect input power wires and output power wires to the same 12V DC battery terminals? (of course positive to positive and negative to negative)

    ...


    2021-12-11 09:41 Andrea Rossi

    Don Z.:

    1- yes

    ...

    Help!!!!!!

    My brain cells are decaying at a rapid rate. I've attempted this calculation and come up with three different answers. It doesn't help that SI redefined all these in 2019, so my ancient (1960) chemistry is probably wrong.

    Given a molecule of molecular weight 1234.5

    Convert a concentration expressed in ng/ml to molecules per cubic micron.

    Mole: Number of Molecules

    https://en.wikipedia.org/wiki/Mole_(unit)

    The mole is defined as exactly 6.02214076×1023 elementary entities.

    Molar Concentration : Moles/Liter

    Molar concentration - Wikipedia


    AMU (Dalton) :
    https://en.wikipedia.org/wiki/Dalton_(unit)
    1.66053906660(50)×10−27

    in kg


    molecules_per_cubic_micron = XXXXXX * nanograms_per_ml


    Edit: a step-by-step explanation would be useful, eg converting ml to cubic microns, kg to ng etc

    COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent


    COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent
    SARS-CoV-2, the etiological agent of the current COVID-19 pandemic, belongs to a broad family of coronaviruses that also affect humans. SARS-CoV-2 inf…
    www.sciencedirect.com


    Abstract

    SARS-CoV-2, the etiological agent of the current COVID-19 pandemic, belongs to a broad family of coronaviruses that also affect humans. SARS-CoV-2 infection usually leads to bilateral atypical pneumonia with significant impairment of respiratory function. However, the infectious capacity of SARS-CoV-2 is not limited to the respiratory system, but may also affect other vital organs such as the brain. The central nervous system is vulnerable to cell damage via direct invasion or indirect virus-related effects leading to a neuroinflammatory response, processes possibly associated with a decrease in the activity of angiotensin II converting enzyme (ACE2), the canonical cell-surface receptor for SARS-CoV-2. This enzyme regulates neuroprotective and neuroimmunomodulatory functions and can neutralize both inflammation and oxidative stress generated at the cellular level. Furthermore, there is evidence of an association between vitamin D deficiency and predisposition to the development of severe forms of COVID-19, with its possible neurological and neuropsychiatric sequelae: vitamin D has the ability to down-modulate the effects of neuroinflammatory cytokines, among other anti-inflammatory/immunomodulatory effects, thus attenuating harmful consequences of COVID-19. This review critically analyzes current evidence supporting the notion that vitamin D may act as a neuroprotective and neuroreparative agent against the neurological sequelae of COVID-19.


    . Conclusion and prospects

    COVID-19 is a complex and still poorly understood disease whose adequate characterization remains to be elucidated. This, as well as the ability to predict the increasingly frequent long-term neurological and neurocognitive-associated pathologies of the disease, call for further investigation [107]. Rigorous and systematic longitudinal follow-up studies of COVID-19 patients will provide the required data to evaluate the diagnosis, prognosis and treatment of these neurological sequelae. In the meantime, vitamin D monitoring and supplementation in both current COVID-19 patients and in those who have recovered should be considered as a possible strategy to add to our therapeutic arsenal from a neuroprotective and/or neuro-reparative perspective (Fig. 3).


    Fig. 3

    Download : Download high-res image (130KB)Download : Download full-size image

    Fig. 3. SARS-CoV-2 invasion leads to a neuroinflammatory and neurodegenerative process due to a potentially connected reduction in the angiotensin II converting enzyme (ACE2) activity. Vitamin D controls this enzyme, which has neuroprotective and neuroimmunomodulatory activities. In addition, vitamin D, among other anti-inflammatory/immunomodulatory actions, can down-modulate the effects of neuroinflammatory cytokines, reducing COVID-19's detrimental effects. This research supported the hypothesis that vitamin D may function as a neuroprotective and neuroreparative agent against the neurological consequences of COVID-19. Signs (+) or (−) mean stimulation and inhibition, respectively. Signs (+) or (−) mean stimulation and inhibition respectively. 1,25(OH)2D = 1,25-dihydroxyvitamin D; ACE = angiotensin converting enzyme; ACE2 = angiotensin converting enzyme 2; VRD = vitamin D receptor; IL-34 = interleukin 34; IL-4 = interleukin 4; IL-10 = interleukin 10; TGF-β = transforming growth factor-beta; ROS = reactive oxygen species; iNOS = inducible nitric oxide synthase; GDNF = glial cell-derived neurotrophic factor; NGF = neurotrophin nerve growth factor; GSH = reduced glutathione; BDNF = brain-derived neurotrophic factor.

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