Clearance Items

  • As so often happens in Russ George's blog, technical detail is minimal. His discussion of the Nature article largely involves personal reminiscences that portray him as already having explored much of the territory that the authors of the article are now publishing on.

    Has Russ George published any of this work? He says he has given talks and so on, but these are ephemera. Has he published any of it?

  • Has Russ George published any of this work? He says he has given talks and so on, but these are ephemera. Has he published any of it?

    He has published 7 papers as far as I know. The most recent one was in 2000. See:

    In the "All Authors" box, enter "George, R." The paper 2014 is by another person George, Robert.

    The 1994 paper is an interview with Srinivasan. I recommend it.

  • Kinda like how e-catworld doesn't upset the peace with Rossi? ;)

    That is unfair. ECW chose to be that way, David had his arm twisted...twice! It was either comply or lawyer up, and that costs money. I don't like this type of legal bullying any more than you. Especially so in this case, where he was often the one initiating the insults, and on the very thread he started. Bad episode that leaves a bad taste in my mouth.

  • He has published 7 papers as far as I know. The most recent one was in 2000. See:

    Hi Jed. I hadn't appreciated that your database is so user friendly. It's terrific!

    Among the Russ George publications ... what is the nature of the ones that do not have links? They also do not show have citation information. I am thinking of the ones between 1995-97 with record numbers 1362, 1363, and 1341.

  • If anyone is still interested, I am continuing the discussion of blood testing from a drop of blood and Theranos here. The claim by one or more posters was that there are ways to do hundreds or thousands of tests on a drop of blood. As I responded, that is true but sort of trivial. These are not every day clinical laboratory tests but rather immunoassays or DNA SNIP identifications. See for example:…blood-testing-stand-today and…g-startups-next-theranos/

    The multi billion dollar prize will go to whoever is the first to perform on a single drop of blood the actual tests used to evaluate health in a clinical laboratory setting. According to Scripps Health, these would include (in no particular order):

    Comprehensive metabolic panel (see below)

    Vitamin D 25-Hydroxy,

    TSH (thyroid stimulating hormone) test

    Complete blood count (CBC)

    HbA1C (blood sugar)

    Occult blood in stool and urinalysis

    HDL and LDL levels

    High sensitivity C-reactive protein

    NMR Lipoprotein testing (advanced cholesterol test)

    Prostate specific antigen – PSA (men)


    The comprehensive metabolic panel (CMP) is a frequently ordered panel of 14 tests that gives a healthcare provider important information about the current status of a person's metabolism, including the health of the kidneys and liver, electrolyte and acid/base balance as well as levels of blood glucose and blood proteins. Abnormal results, and especially combinations of abnormal results, can indicate a problem that needs to be addressed.

    The CMP includes the following tests:

    Glucose - energy source for the body; a steady supply must be available for use, and a relatively constant level of glucose must be maintained in the blood.

    Calcium - one of the most important minerals in the body; it is essential for the proper functioning of muscles, nerves, and the heart and is required in blood clotting and in the formation of bones.


    Albumin - a small protein produced in the liver; the major protein in serum

    Total Protein - measures albumin as well as all other proteins in serum


    Sodium - vital to normal body processes, including nerve and muscle function

    Potassium - vital to cell metabolism and muscle function

    CO2 (carbon dioxide, bicarbonate) - helps to maintain the body's acid-base balance (pH)

    Chloride - helps to regulate the amount of fluid in the body and maintain the acid-base balance

    Kidney Tests

    BUN (blood urea nitrogen) - waste product filtered out of the blood by the kidneys; conditions that affect the kidney have the potential to affect the amount of urea in the blood.

    Creatinine - waste product produced in the muscles; it is filtered out of the blood by the kidneys so blood levels are a good indication of how well the kidneys are working.

    Liver Tests

    ALP (alkaline phosphatase) - enzyme found in the liver and other tissues, bone; elevated levels of ALP in the blood are most commonly caused by liver disease or bone disorders.

    ALT (alanine amino transferase, also called SGPT) - enzyme found mostly in the cells of the liver and kidney; a useful test for detecting liver damage

    AST (aspartate amino transferase, also called SGOT) - enzyme found especially in cells in the heart and liver; also a useful test for detecting liver damage

    Bilirubin - waste product produced by the liver as it breaks down and recycles aged red blood cells…nsive-metabolic-panel-cmp

    The above are the tests in common use world wide in clinical labs. If you know of a company contemplating making a machine which can perform a worthwhile subset of these on a drop of blood, I'd love to see the reference and the link. And I would certainly invest if credible testing had been done and appropriately reported. But then again, so would every venture capitalist be willing. Yet, this is what Theranos was implying they could deliver. Why else would they have been valued in the billions? For performing esoterica?

  • It would seem that all the tests on the comprehensive metabolic panel can be performed by immunoassay nowadays - even blood counts. For TSH, immunoassay is now the recommended testing method, and the others are either regular tested by immunoassay, or such tests are being assesed for accuracy by researchers.

    And is the "NMR" lipoprotein test really all that necessary, or are Scripps Health just trying to cash in with expensive tests? The Havard Medical School seems to think so:

    "It sounds like you had advanced lipoprotein testing, which is a more detailed and also more expensive version of a standard cholesterol or lipid test. In general, I'm not a fan of this type of testing, because there is no solid evidence that the results are useful in any concrete way or provide information that can improve a person's health."…ipoprotein-testing-useful

    I would imagine that Genalyte already use several immunoassays from the above list in the 60 or so tests they currently perform.

  • Among the Russ George publications ... what is the nature of the ones that do not have links? They also do not show have citation information.

    Those are papers I have not uploaded. Some I do not have. Others I have, but the author or publisher did not give me permission to upload.

    There is no citation information because I did not bother to enter it into the database. When I don't have permission to upload, I don't add the abstract or other information. There are 2,586 papers in the database that I have not uploaded, so it would be a lot of work to enter all that information. I don't see the point. The paper is probably not available anywhere else, except perhaps behind a paywall where no one will read it anyway.

    It is a little complicated. The database is maintained in EndNote format. It was compiled by Ed Storms and me. There are 4,530 items in it. There are at present ~1,944 documents uploaded, which are in 1,099 computer files. Some computer files have multiple documents, such as proceedings and issues of the JCMNS. As I said, that leaves 2,586 documents in the database that I do not have, or I don't have permission to upload. I am not going to go to the trouble to add all those abstracts and whatnot. A few abstracts were added by Ed Storms, and a few more are now added automatically when I download info. from DOI links. But when I wrote the program that converts EndNote to the MySQL files, I decided to simply life by not transferring those few.

    I also did not bother to add all of the old papers in proceedings to the EndNote file. They are out there, but not indexed. So that's why I say there are tilde (approx) 1,944 documents. I do not have an exact count. There are 1,944 that I went to the trouble to index.