Covid-19 News

  • Drug-Induced QT Prolongation and Death


    This is deceptive nonsense Robert.


    From the abstract:

    Prolongation of the QT interval can predispose to a potentially fatal polymorphic ventricular tachycardia called torsades de pointes (TdP). Although usually self-limited, TdP may degenerate into ventricular fibrillation and cause sudden death.

    Some medications that cause QT prolongation and possible TdP are commonly used in general practice. This paper presents a case of sudden death that is likely from drug-induced TdP.

    https://pubmed.ncbi.nlm.nih.gov/20222297/


    Which appears to support my point: That no-one ever died of a prolonged QT interval.


    So it seems yet another Robert Bryant discussion has degenerated into disingenuity, incoherent wordplay, and ironic claims of diversion.


    To be expected, but not encouraged.

  • This is deceptive nonsense Robert.

    Stop name calling as you like THH both have completely failed to even superficially understand medicine most basics facts like the knowledge about LD50 doses one never should even approach... (remember the mice...)

    QT prolongation has been discussed already in countless posts within this thread. If you can add substance then clearly identify what new you have and reference a paper.

    Just to give you an example. If it happens while you drive a car it will be deadly in the worst case. In Africa where most people don't drive they simple will have a rest.


    how did the RECOVERY pharmacist justify such high levels (2400 mg in 1 day) straight up ,in so many patients?

    This would be grounds for litigation in the USA..

    I still hope somebody will sue these Mengele apprentices that intentionally killed a large number of defenseless people!



    National Institute of Health (NIH) Recommends Against Early Treatment for COVID-19

    https://covexit.com/national-i…y-treatment-for-covid-19/

    The same here: If the pandemic is over I hope these guys will be sued too for recommending a friends (Gilead) drug that has not the slightest impact on the health of a CoV-19 sick person and for preventing true medical help!


    CONCLUSIONS

    These Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens appeared to have little or no effect on hospitalized COVID-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay. The mortality findings contain most of the randomized evidence on Remdesivir and Interferon, and are consistent with meta-analyses of mortality in all major trials. (Funding: WHO. Registration: ISRCTN83971151, NCT04315948)

  • Maybe hydroxychloroquine isn't the the problem but it's interaction with azithromycin


    Using hydroxychloroquine together with azithromycin can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.


    Maybe using doxycycline instead as there are no adverse interactions with hydroxychloroquine and zinc

  • So it seems yet another Robert Bryant discussion has degenerated into disingenuity

    I was wrong .. Google is not Zeus's friend

    Zeus appears to be not able to connect dots together.. but twists them to say it supports his point

    ....that the patient did not die from QT elongation..???


    Prolongation of the QT interval can predispose to a potentially fatal polymorphic ventricular tachycardia called torsades de pointes (TdP). Although usually self-limited, TdP may degenerate into ventricular fibrillation and cause sudden death.

    Some medications that cause QT prolongation and possible TdP are commonly used in general practice. This paper presents a case of sudden death that is likely from drug-induced TdP.


    The patient died from Torsades de Pointes... drug induced via QT elongation..

    This is why QT elongation is the subject of multiple warnings in pharmacological tomes and largely why quinine has been banned from most hospital formularies...in the last two decades.. it was dropped around 2000 in Australia


    the old gin and tonic is frowned upon.

    "Quinine has dose-dependent QT-interval-prolonging effects and should be used with caution in patients with risk factors for QT prolongation or in those with atrioventricular block.


    https://www.gov.uk/drug-safety-update/quinine-reminder-of-dose-dependent-qt-prolonging-effects-updated-medicine-interactions#:~:text=Quinine%20has%20dose%2Ddependent%20QT,in%20those%20with%20atrioventricular%20block.


    QT morbitdity is rare in the normal young healthy patient but it is unknown what the effect of 1 billion little Covid stickies is on the aged cardiovascular system which is a very good reason not to give 2400 mg/d of HCQ..

    which is why I would not have signed off on the RECOVERY dosage...too many unknowns.. why go so unprecedentedly high? 1561 patients?

    Goodness gracious me..

    Zeus has little idea of the complexity of modern clincal pharmacology ..

  • Gosh, they've allowed me back in, after hacking for several hours. Well what more can I say - I have to avoid any sensitive issues with the 'forces that be' breathing down my neck. Their latest venture is trying to freeze my bank accounts but fortunately that great money-laundry business HSBC will have no truck with them. Come on! Are you going to throw every state pensioner off your pay list?????? I can only appeal to Team Google to act in a moral, empathic, fair, honest way on the side of justice etc etc. Anyway, so what's up doc? What's new on the COVID scene???? Nothing much it seems THHuxleynew is still grinding on that antivirals will never work whilst others with more common sense but are perhaps more intelligent (eg Wyttenbach who is also unconstrained in his analysis living in the somewhat privileged German free state of Switzerland). My money would be on the latter being correct anytime with his purely objective analysis of the facts as they stand. No bias there!!! And, after all he is a genius inventing a totally novel view of theoretical physics.:)

  • Hydroxychloroquine, nitazoxanide and ivermectin have similar effects in early COVID-19

    - a head-to-head comparison of the Pre-AndroCoV Trial.


    Conclusion: Hydroxychloroquine, nitazoxanide and ivermectin seem to be similarly

    effective for overall clinical outcomes in COVID-19 when used before seven days of

    symptoms, and overwhelmingly superior compared to untreated COVID-19 population,

    even for those outcomes not influenced by placebo effect, at least when combined with

    azithromycin, and vitamin C, D and zinc in the majority of the cases. Between these

    drugs, nitazoxanide demonstrated the strongest broad spectrum antiviral activity,

    plausibility to act as an anti-COVID agent, and safety profile, at least at the time

    of the choice of the drug for the AndroCoV Trial.


    https://www.researchgate.net/p…of_the_Pre-AndroCoV_Trial

  • Two major studies of vaccines against Covid-19, both paused because of potential safety concerns, are set to restart, the companies running them said Friday.


    “The restart of clinical trials across the world is great news as it allows us to continue our efforts to develop this vaccine to help defeat this terrible pandemic,” Pascal Soriot, AstraZeneca’s CEO, said in a statement. “We should be reassured by the care taken by independent regulators to protect the public and ensure the vaccine is safe before it is approved for use.”


    “We as a company have found no evidence the vaccine candidate caused the event, and we have agreed to restart the study,” Paul Stoffels, the chief scientific officer at Johnson & Johnson, said in an interview.


    In both cases, new documents describing potential risks for both researchers and volunteers have been prepared, and must be approved by a centralized institutional review board, one of several groups charged with protecting patients in the trial.



    https://www.statnews.com/2020/…39373-5ada155752-44567417

  • Alan Smith

    Changed the title of the thread from “Covid-19 (WuFlu) News” to “Covid-19 News”.
  • Conclusion: Hydroxychloroquine, nitazoxanide and ivermectin seem to be similarly

    effective for overall clinical outcomes in COVID-19 when used before seven days of

    symptoms, and overwhelmingly superior compared to untreated COVID-19 population,

    even for those outcomes not influenced by placebo effect, at least when combined with

    azithromycin, and vitamin C, D and zinc in the majority of the cases.

    There is only a small critic. The overall usage of 3 x Ivermectin standard dose is low and OK for most. But for > day 5 others recommend increased dosage up of to 12x normal normal = 20mg or 0.mg/kg body weight) in total.

    The problem is that with a higher viral load a lot of Ivermectin is used for function 1= blocking the virus before entry of a cell and less is available for function 2: blocking the viral replication in the cell!

    This might be the main reason because all three drugs work about the same as the other two only have function 1: (So far I did read..)

  • Nsp7 and Spike Glycoprotein of SARS-CoV-2 Are Envisaged as Potential Targets of Vitamin D and Ivermectin


    https://www.preprints.org/manuscript/202005.0084/v1


    Abstract

    COVID-19 has emerged as deadly pandemic worldwide with no vaccine or suitable antiviral drugs to prevent or cure the disease. Because of the time-consuming process to develop new vaccines or antiviral agents, there has been a growing interest in repurposing some existing drugs to combat SARS-CoV-2. Vitamin D is known to be protective against acute respiratory distress syndrome (ARDS), pneumonia and cytokine storm. Recently it has been used as a repurposed drug for the treatment of H5N1 virus-induced lung injury. Circumstantial evidences indicate that people with low level of vitamin D are more susceptible to SARS-CoV-2. Although, vitamin D was suggested to interfere with viral replication, its interaction with any SARS-CoV-2 protein is unexplored yet. Beside this, ivermectin, a well-known anti-parasitic agent, exhibits potent anti-viral activities in vitro against viruses such as HIV-1 and dengue. Very recently, ivermectin has been found to reduce viral load of SARS-CoV-2 in vitro. We have analyzed available structures of SARS-CoV-2 proteins to identify probable binding partner(s) of vitamin D and ivermectin through knowledge-based docking studies and figured out possible implication of their binding in SARS-CoV-2 infection. Our observations suggest that the non-structural protein nsp7 possesses a potential site to house 25-hydroxyvitamin D3 (VDY) or the active form of Vitamin D, calcitrol. Binding of vitamin D with nsp7 likely to hamper the formation of nsp7-nsp8 complex which is required to bind with RNA dependent RNA polymerase (RdRP), nsp12 for optimal function. On the other hand, potential binding site of ivermectin has been identified in the S2 subunit of trimeric spike(S) glycoprotein of SARS-CoV-2. We propose that deeply inserted mode of ivermectin binding at three inter-subunit junctions may restrict large scale conformational changes of S2 helices which is necessary for efficient fusion of viral and host membrane. Our study, therefore, opens up avenues for further investigations to consider vitamin D and ivermectin as potential drugs against SARS-CoV-2.

  • Could ASPIRIN be the first over the counter treatment for coronavirus? Hospitalized

    patients already taking the drug daily were 47% less likely to die of COVID-19

    https://www.dailymail.co.uk/health/article-8881285


    Whiteboard Doctor - Oct-26

    Ivermectin, Azithromycin, Vitamin D Combination Therapy For Early, Outpatient COVID-19: New Study!

    - Small sample size of early symptomatic patients, very positive results


    Trial Site News - Oct-26

    Clinical Trials and Research News Weekly Roundup | USAMRDC Develops COVID-19 Vaccine Candidate SpFN

    - U.S. Army vaccine, RLF-100 provides 9X increase in survival rate in late stage COVID

    - MATH+ protocol includes ivermectin for prophylaxis and early treatment


    Drbeen Medical Lectures - Oct-27

    Ranitidine Bismuth Citrate (RBC) For COVID-19

    - RBC (aka Zantac) appears to be potently anti-COVID-19

    Referenced paper - SARS-Coronavirus-2 Nsp13 Possesses NTPase and RNA Helicase

    Activities That Can Be Inhibited by Bismuth Salts

    https://www.ncbi.nlm.nih.gov/p…2250_2020_Article_242.pdf


    “Remdesivir for COVID-19” Study accidentally proved effectiveness of Hydroxychloroquine

    https://wattsupwiththat.com/20…ss-of-hydroxychloroquine/

  • This from Web MD

    COVID Syndrome Seen in Kids Also Strikes Adults

    https://www.webmd.com/lung/new…-kids-also-strikes-adults



    When the new coronavirus pandemic first began, respiratory distress immediately became the hallmark of severe COVID-19 illness. News reports focused on the inability to breathe, low oxygen saturation levels and the alarming need for ventilators.


    But six months later, experts are becoming increasingly concerned about a very different COVID-19 phenomenon, one that spares the lungs only to take direct aim at the patient's heart, digestive tract and nervous system.

  • https://www.cnn.com/world/live…50da829c313d5861590c8bb08

    British study shows evidence of waning immunity to Covid-19

    From CNN's Jen Christensen


    A study of hundreds of thousands of people across England suggests immunity to the coronavirus is gradually wearing off -- at least according to one measure.


    Researchers who sent out home finger-prick tests to more than 365,000 randomly selected people in England found a more than 26% decline in Covid-19 antibodies over just three months. . . .

  • See, I told you so. The emerging clinical trials are showing synergistic actions between the different anti-bat components, ivermectin potentiating HCQ action and even better with Zn, D3 etc. Er so what's up doc? I am still being severely hacked by I presume TG looking for our secret cold fusion reagents we are working out with Ecalox. So, Mum's the word until we have secured at least UK patent protection. But its expensive!!!!! Lend us some of your MILLIONS TG????? Maybe we could cut a deal?????:):):)

  • Vitamin D has its advocates, but some scientists say it's a waste of time to study it as a treatment for the virus.

    V-D3 is not a treatment! It in general helps your body to fight off viral infections and prevents the cytokine storm. Thus usually patients with high V-D levels only see mild symptoms!

    Do not believe the WHO dose of 500 ICU/daily. This is of no help. To fill up your depot you need a few days with at least 3000IU's of V-D3. And please take it with a soup spoon of oil!