Covid-19 News

  • Cummings is interesting and probably dangerous.

    Not sure why he was in the SAGE meetings. Obviously the Guardian and others see sinister intents, maybe he was just observing.


    Dominic Cummings ideas for the Civil Service

    "...governments have long expressed their dissatisfaction with the Whitehall machine. The critique of the civil service establishment was set out most eloquently in the 1968 Fulton report commissioned by Harold Wilson’s administration. Officials were ‘generalists’ trained in arts and humanities subjects at Britain’s ancient universities. They lacked specialist knowledge and technical expertise. Civil servants were poor managers. They presided over a culture of mediocrity which perpetuated Britain’s relative economic decline. Fulton’s recommendations included bringing more trained scientists into Whitehall, while training mandarins in management effectiveness. Sound familiar? The attacks on the civil service then continued into the 1980s and 1990s. Margaret Thatcher threatened to ‘deprivilege Whitehall’ while her ideological soulmate, Ronald Reagan, spoke of ‘draining the swamp’ in Washington. Under Blair’s New Labour governments, more political advisers were brought onto departments, while there was an air of mistrust towards permanent officials. Yet for all that, the Whitehall model survived."


    Funny how history repeats yet the memory of the electorate is short.

    Cummings has a dream to clear out the entrenched arts and humanities crowd from the British Civil Service and put in scientists and others with a background in more "practical" areas. I suppose this goes back to the two cultures argument of C P Snow.

    This sounds like a good idea, at face value, that might be applauded by many here.

    However elsewhere in the linked article it says he wants to challenge the neutrality and independence of the civil service that enables them to speak truth to power such that "His aim is to install a ‘them and us’ model where officials merely carry out the wishes of ministers, focusing on the delivery and implementation of policy."


    So basically we have a "populist" government, like many other countries, who see any opposition from the media, the civil service, the judiciary, or politicians from their own party or opponent parties, as something to be shut down where possible and circumnavigated or ignored otherwise, even to the extent of shutting down parliament when it suited them. So with very loosened checks and balances on democracy, when the decisions are good then good stuff gets done but when the decisions are bad then bad stuff gets done regardless.


    As populism seems to have been a reaction to the 2008/9 crash it will be interesting to see whether there is a backlash agains populism from this particular Covid crisis or whether voters turn to even more anti-establishment figures.

  • We here had 2+ weeks warm and very dry weather (did help for a sharp decline of infections). UK is never in this category and thus will never see any help from climate.


    https://blog.metoffice.gov.uk/…y-and-sunny-april-so-far/


    It has been a dry and sunny picture for the first half of April.

    Provisional mid-month statistics (1-15th April) show areas such as the City of London, Kent, Surrey, West Sussex and the Isle of Wight having recorded around half a millimetre of rainfall so far this month, just 1% of the monthly average. In fact, for many areas of the UK there has been no appreciable rainfall since 19th March.


    Counterfactuals do not make for good argument.

    • Official Post

    rubycarat I can send you some chloroquine or hydroxychloroquine if you cannot obtain any supply there. Antiviral and immunosuppressive when it is needed at the cytokine storm stage. You couldn't design a better anti-COVID 19 biochemical, if taken with 200mg Zinc sulphate and either azithromycin or doxycycline. Other Anti Bat components can be found onlline.

    THANK YOU Dr. Richard. I could get some if I need it. My plan is the kill the virus early on while it's still weak and in small number - first sign of anything awry. I will survive!

    • Official Post

    rubycarat I hope you stay well. But if you are unfortunate enough to get COVID-19, please seek and follow the advice of a qualified physician, (an M.D. or D.O in the US).

    THANK YOU seven, I understand that there are waves of possible drugs and nothing definitive at this time. Doctors are trying all kinds of things, and some seems to work, but not all the time, ... etc. I will seek medical attention at the first sign of shortness of breath. But as I said, I am determined to stay healthy and when COVID knocks, I'll dispatch it quickly.

    • Official Post

    As an observer from the UK it seems to me that in the USA each state is doing its own thing, kind of like individual countries.

    So how critical is the cross border contamination issue likely to be to in the ability of the USA to control the virus?


    That is the big question. In the state of New Mexico, sheriff's just closed all the roads into a small town called Gallup because they were having an uncontrollable outbreak.


    Each state is in the U.S. is run by a Governor, and the Governor determines what happens. However, the political divide has many Governors in opposition to City leaders, called Mayors. So for instance, a state may be "open", but the largest city in the state will remain closed by decree of the Mayor.


    It appears that the states that are opening are not getting what they wanted out of it. When a restaurant can only open at 25% capacity, they can't make any money, and then close back down. Also, many people are just not coming out, so retail stores have not seen the people they would like. The people themselves appear to be saying they are not ready to open.

  • Pseudo-Science behind the Assault on Hydroxychloroquine

    Leo Goldstein on wuwt..

    • HCQ-based treatments are effective in treating COVID-19, unless started too late.
    • Studies, cited in opposition, have been misinterpreted, invalid, or worse.
    • HCQ and AZ are some of the most tested and safest prescription drugs.
    • Severe COVID-19 frequently causes cardiac effects, including heart arrhythmia. QTc prolonging drugs might amplify this tendency.

    Millions of people regularly take drugs having strong QTc prolongation effect, and neither FDA nor CDC bother to warn them. HCQ+AZ combination, probably has a mild QTc prolongation effect. Concerns over its negative effects, however minor, can be addressed by respecting contra-indications.

    • Effectiveness of HCQ-based treatment for COVID-19 is hampered by conditions that are presented as precautions, delaying the onset of treatment. For examples, some states require that COVID-19 patients be treated with HCQ exclusively in hospital settings.


    the manufacturer of a competing drug remdesivir. Among those who failed to disclose such links are 2 out of 3 of its co-chairs.

    • Despite all the attempts by certain authorities to prevent COVID-19 treatment with HCQ and HCQ+AZ, both components are approved by FDA, and doctors can prescribe them for COVID-19

    https://wattsupwiththat.com/20…lt-on-hydroxychloroquine/





  • NIH Gilead switched the Goalposts half way thru the trial


    From reduced mortality to reduced bed stay..time


    Perhaps they realised that the

    Remdesivir trial wasn't bringing mortality down.


    As indicated in the Lancet paper



    However..

    the FDA did approve Remdesevir as prophesized by Walid Gellad on April 30

    yes, and with Zn

    Don't count on Remdesevir... the NIH study is more about its share price than mortality

    It is no balm of Gilead

  • My plan is the kill the virus early on while it's still weak and in small number - first sign of anything awry.

    While I wish you good luck with that plan, the result of various suggested treatments for this virus can not be guaranteed. This is a weird disease and for some patients, things go bad rapidly and with little warning. It's hard to overemphasize this. Someone can literally feel fine and be actively doing things and be on a ventilator 8 hours later. Keep in mind that there is absolutely no proven preventative or cure for the virus, regardless of some glowing claims you read here or elsewhere. And only remdesivir has been shown to be of some probable modest help. It can only be given intravenously at present.


    So I don't know how anyone can expect to reliably detect much less kill the virus early in the disease. If you are young, the disease is most often mild but even then, you can not rely on it. It is monumentally unpredictable. I mentioned earlier that the reaction of any individual to the virus may be in part genetic and there is some evidence now for that.


    The point is, whatever else you do or take, be prepared to get immediate effective help if things turn sour. While there is no cure, many doable interventions in or out of the ICU can help patients survive and minimize damage. These interventions are mostly very complex and require very expert management. There is probably no harm in vitamins, zinc, and other dietary supplements but even though I take some myself, I know of no definitive studies to show that those do anything preventative, much less curative, in any stage of the disease. And treat yourself with prescription drugs without medical supervision at your own peril.

  • Quote

    #3,453 / RobertBryant wrote:

    HCQ-based treatments are effective in treating COVID-19, unless started too late.

    yes, and with Zn


    I have an automatic search in Google for the issue. And also I have an email subscription to the New England Journal of Medicine COVID-19 publications. What I have read so far about HCQ with or without anything else is inconclusive. Yes, there are a few studies suggesting it works but all are badly designed and/or performed. And there are some studies, equally awfully designed and done, which suggest it doesn't and can even increase the death rate (I doubt that but how would we know for sure?). When it comes to HCQ in any combination, to take or not to take is a very hard decision. It does nobody any good to write that these treatments "are" effective. Based on what I saw, that can't be right. At best, you can say they may be effective but they may not and there is also the possibility they may do harm.


    Should I be unfortunate enough to get this disease, my first choice would have been HCQ+Azi maybe with zinc. With current evidence, I probably would opt for remdesivir first and before doing anything, I would have some talks with local physicians who have actually used HCQ and combinations. By now there are quite a few in most places.


    I know this may be hard for the "Gung Ho!" types to understand but before making definitive statements on HCQ etc., we must await randomized, placebo-controlled or multi-arm, matched case, studies, sometimes abbreviated as RCT's (randomized clinical trials). There I go getting preachy again. I just hate to see obvious mistakes about this stuff because getting to the truth about it is so important.

  • With current evidence, I probably would opt for remdesivir

    What I have read so far about HCQ with or without anything else is inconclusive

    We await the mortality figures from the complete NIH study..when it is published in full.

    .so far the NIH interim results are

    "Mortality results also favored remdesivir (8.0% for remdesivir compared to 11.6% for placebo), but, unlike the recovery results,

    this difference was not statistically significant. It was close, though.

    The standard cutoff for statistical significance is having a so-called p-value less than 0.05; the p-value here was 0.059."


    This compares with the recent preprint of the Wuhan HCQ trial on critical care patients.

    "

    HCQ effect on critically ill patients.

    n=520,(-HCQ) n=48 (+HCQ).. Feb1 - Apr8

    HCQ Dose = 200 mg HCQ BD for 7-10 days


    survival (81% versus 54%) a was significantly increased (p<0.001)


    https://www.medrxiv.org/conten…04.27.20073379v1.full.pdf

  • Trust the biochemical evidence for using HCQ - you can't argue interminably against a dose response relation. There should also have been further in vitro tests looking at the potentiality effects of raising Zn levels and establishing the best antibiotics to use in combination. And what about all the other chloroquine analogues which could be more effective or have fewer side effects?

  • Should I be unfortunate enough to get this disease, my first choice would have been HCQ+Azi maybe with zinc. With current evidence, I probably would opt for remdesivir first and before doing anything, I would have some talks with local physicians who have actually used HCQ and combinations. By now there are quite a few in most places.

    HCQ effect on critically ill patients.

    n=520,(-HCQ) n=48 (+HCQ).. Feb1 - Apr8

    HCQ Dose = 200 mg HCQ BD for 7-10 days


    survival (81% versus 54%) a was significantly increased (p<0.001)


    https://www.medrxiv.org/conten…04.27.20073379v1.full.pdf


    This is a key statement: If a doctor tells you to opt for remdesivir then immediately quit the hospital and look for a place that uses the well known working drugs (First choice for severe cases Ivermectin - see summary above) . Remdesivir has shown no help for ICU survival in all places I know but none were allowed to officially report this. Fact is remdesivir only delays your death as Kaletra does too.


    The use of remdesivir for a critical patient is highly unethical and I would immediately sue the doctors & the hospital.

    • Official Post

    Dr Richard (particularly) video spotted by Bob Greenyer. Ends up in Senegal where they are using CLQ with top results,


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  • Here's a very good review of why we should all be using chloroquine, one of the authors is Didier Raoult so some of you can dismiss it out of hand as being right wing propaganda if you like. But its just the science. The action of chloroquine in preventing thrombosis due to clumping of red blood cells as described in the above video is probably related to blocking hemagglutinins.

    New insights on the antiviral effects of chloroquine ... - NCBI

    www.ncbi.nlm.nih.gov › pmc › articles › PMC7118659
    by CA Devaux - ‎Cited by 91

    Chloroquine and the 4-aminoquinoline drug hydroxychloroquine belong to ... was found to be associated with uncoating, thus blocking its entire replication cycle. ... to humans involves progressive loss of hemagglutinin-esterase lectin activity) ..

    • Official Post

    Two steps forward, one step back. Yesterday, Trump again said he "was very excited about HCQ". That sent the media into another round of HCQ bashing. Just when things were settling down a bit, and science was starting to rule the discussion, and not politics.


    Personally, I have seen enough that when/if I get it, and need to be hospitalized, I will be screaming "I demand Dr. Richards anti BAT treatment...NOW", as they wheel me into the ICU. Hopefully they don't divert me into the Psych ward instead.

    • Official Post

    Even though the US has 30 million unemployed due the shut down, there has IMO been a false sense of optimism that somehow things were not all that bad economically. That once states reopen, things would quickly get back to normal.


    But the real fallout is now starting to hit, and reality setting in with major corporations just starting to announce their own cutbacks due the gloomy forecasts. So things will get much worse unfortunately. That is probably the main reason why some of these governors are opening their states before the Federal guidelines for re-opening are met.


    Good example is United Airlines. They have 13,500 pilots, and their union just informed them the companies bookings through the summer are down almost 100%. That they should "be prepared for a 2000 pilot airline" until the economy rebounds. Some fleets (airplane types) will be mothballed. You may not realize how hard that is to accomplish with pilot positions, but just the retraining alone makes it a costly, and time consuming mess.


    They are just the tip of the iceberg though. Many more companies will be announcing similar tough measures in the days and weeks to come to try and survive.

  • Shane D. Good luck with that, we'll all club together on LF and try to ensure all our members have a ready supply of Anti Bat if required! Let's look on the bright side maybe Trump's excitement might eventually lead to a positive outcome. Particularly since he will be ending the lock down soon and antiviral treatments will become absolutely essential. Telemedicine, track and tracing, antibody testing, antivirals, mass fever treatment. Then get the economy moving again.:)

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