Sceletium looks interesting too, but there are just so many plant products to screen:
3.21. Sceletium tortuosum (L.) N.E. Brown (Aizoaceae)
The ethanolic and ethyl acetate extracts prepared from the whole part of Sceletium tortuosum, distributed throughout southern Africa, were investigated for their inhibitory activity against HIV-1 enzymes including protease (PR), reverse transcriptase (RT) and integrase (IN) [172]. The HIV-1 RT inhibition testing had IC50 values of <50 and 121.7 ± 2.5 μg/mL for ethanol and ethyl acetate extracts, respectively. In addition, both extracts had also inhibited HIV-1 PR with IC50 values < 100 μg/mL. Sceletium tortuosum might be a potential source of new lead compounds in the development of new anti-HIV compounds [67].