...another possible anti-covid-19 remedy camostat mesylate :
We next analyzed whether TMPRSS2 usage is required for SARS-CoV-2 infection of
204 lung cells. Indeed, camostat mesylate significantly reduced MERS-S-, SARS-S- and SARS-2-S205 but not VSV-G-driven entry into the lung cell line Calu-3 (Figure 4C) and exerted no unwanted
206 cytotoxic effects (Figure S3 panel C). Similarly, camostat mesylate treatment significantly
207 reduced Calu-3 infection with authentic SARS-CoV-2 (Figure 4D). Finally, camostat mesylate
208 treatment inhibited SARS-S- and SARS-2-S- but not VSV-G-driven entry into primary human
209 lung cells (Figure 4E). Collectively, SARS-CoV-2 can use TMPRSS2 for S protein priming and
210 camostat mesylate, an inhibitor of TMPRSS2, blocks SARS-CoV-2 infection of lung cells.
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7 Mar 2020 - Coronavirus Drug Research: German Researchers Identify Japanese Drug, Camostat Mesylate That Could Be Repurposed To Treat Covid-19.