Mutations Strengthened SARS-CoV-2 Infectivity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375973/
Results
Impacts of existing RBD mutations
Global analysis To investigate the influences of existing S protein RBD mutations on BFE of S protein and ACE2, the 24715 complete SARS-CoV-2 genome samples deposited at GISAID [30] are compared with the first genome sequence of SARS-CoV-2 collected on January 5, 2020 [6]. The resulting 11904 single mutations are found in six distinct clusters as shown in Table 1 [5] and Figure 1 . There are 725 existing non-degenerated mutations on SARS-CoV-2 S protein. Among them, 89 mutations occurred on the RBD, which are relevant to the binding oSARS-CoV-2 S protein and ACE2. Furthermore, 52 out of 89 mutations are on the receptor-binding motif (RBM), i.e., the region of RBD that is in direct contact with the ACE2.